Disruption of programmed masticatory movements in unilateral MPTP-treated monkeys as a model of jaw movement abnormality in Parkinson's disease
Disruption of programmed masticatory movements in unilateral MPTP-treated monkeys as a model of jaw movement abnormality in Parkinson's disease
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DOI：
10.1007/s00702-012-0768-0
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发表时间：
2012-08-01
影响因子：
3.3
通讯作者：
Koshikawa, Noriaki
中科院分区：
文献类型：
--
作者：
Adachi, Kazunori;Kobayashi, Masayuki;Koshikawa, Noriaki
虽然帕金森病的运动障碍可以影响先天的程序性过程，如咀嚼下颌运动，但这种异常的病理生理学尚不清楚。本研究采用高速视频信号处理的数字分析方法，跟踪放置在嘴巴周围的三个点，记录单侧1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）治疗的猴子的咀嚼运动。该系统分析了咀嚼红薯片时下颌运动地形的位移、速度和周期持续时间。在接受MPTP进入右颈动脉的猴子（n = 3）中，正电子发射断层扫描显示，相对于对侧半球，(E)- n -（3-碘丙基-2-烯基）-2 β -碳[C-11]甲氧基-3 β -（4-甲基苯基）北tropane （[C-11]PE2I）与右尾状核、壳核、伏隔核和黑质的多巴胺转运体的结合明显减少。这些猴子表现出左前肢和后肢运动不足。在咀嚼过程中，mptp处理的猴子优先咀嚼左侧，而未处理的猴子（n = 3）则没有咀嚼右侧的偏好。在mptp治疗的猴子中，垂直开合运动的振幅降低，下颌运动的侧向分量轻微但显著增加。下颌水平运动各阶段的速度均降低。结果，mptp治疗的猴子咬合期持续时间增加，而闭合期持续时间减少。这些发现表明，在咀嚼运动中，mptp治疗的猴子优先咀嚼对侧，多巴胺神经元丢失，下颌运动幅度和速度降低。高速数字运动分析能够定义和量化口面部运动地形的异常，作为帕金森病的标志。
While motor disturbance in Parkinson's disease can affect innate, programmed processes, such as masticatory mandibular movements, the pathophysiology of such abnormalities remains unclear. This study applies digital analysis by high-speed video signal processing that tracks three dots placed around the mouth for recording masticatory movements in unilateral 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys. The system analyzes displacement, velocity and cycle duration of the topography of mandibular movement during mastication of sweet potato slices. In monkeys receiving MPTP into the right carotid artery (n = 3), positron emission tomography indicated significant reduction in the binding of (E)-N-(3-iodoprop-2-enyl)-2 beta-carbo[C-11]methoxy-3 beta-(4-methylphenyl)nortropane ([C-11]PE2I) to the dopamine transporter in the right caudate, putamen, nucleus accumbens and substantia nigra relative to the contralateral hemisphere. These monkeys showed hypokinesia of the left forelimbs and hindlimbs. During mastication, MPTP-treated monkeys chewed preferentially on the left side, while untreated monkeys (n = 3) showed no preference for chewing side. The amplitude of vertical opening and closing movements was reduced in MPTP-treated monkeys, with a slight but significant increase in the lateral component of mandibular movements. The velocity of all phases of horizontal mandibular movements was reduced. In consequence, duration of the occlusal phase was increased, while duration of the closing phase was decreased in MPTP-treated monkeys. These findings indicate that during masticatory movements MPTP-treated monkeys chew preferentially on the side contralateral to loss of dopamine neurons, with reduced amplitude and velocity of mandibular movements. High-speed digital movement analysis is able to define and quantify abnormalities of orofacial movement topography as a sign of parkinsonism.