Sieboldine A, a novel tetracyclic alkaloid from Lycopoldium sieboldii, inhibiting acetylcholinesterase
Sieboldine A, a novel tetracyclic alkaloid from Lycopoldium sieboldii, inhibiting acetylcholinesterase
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DOI：
10.1021/ol035560s
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发表时间：
2003-10-16
期刊：
影响因子：
5.2
通讯作者：
Kobayashi, J
中科院分区：
文献类型：
--
作者：
Hirasawa, Y;Morita, H;Kobayashi, J
从三叶草石蒜中分离到一种新的石蒜生物碱，该生物碱具有前所未有的融合四环环体系，由一个n -羟基的氮杂环壬烷环、一个环己酮、一个环戊酮和一个四氢呋喃环组成。利用二维核磁共振数据和x射线分析对其结构和相对立体化学性质进行了表征。Sieboldine A(1)表现出对乙酰胆碱酯酶的有效抑制活性和适度的细胞毒性。
A novel Lycopodium alkaloid with an unprecedented fused-tetracyclic ring system consisting of an aza-cyclononane ring having a N-hydroxy group, a cyclohexanone, a cyclopentanone, and a tetrahydrofuran ring, sieboldine A (1), was isolated from the club moss Lycopodium sieboldii. The structure and relative stereochemistry were elucidated on the basis of 2D NMR data and X-ray analysis. Sieboldine A (1) exhibited a potent inhibitory activity against acetylcholinesterase and modest cytotoxicity.