Genetically seizure-prone or seizure-resistant phenotypes and their associated behavioral comorbidities
Genetically seizure-prone or seizure-resistant phenotypes and their associated behavioral comorbidities
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DOI：
10.1111/j.1528-1167.2007.01398.x
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发表时间：
2007-01-01
期刊：
影响因子：
5.6
通讯作者：
Gilby, Krista L.
中科院分区：
文献类型：
--
作者：
McIntyre, Dan C.;Gilby, Krista L.
人们质疑杏仁核点燃--一种颞叶癫痫模型--是否受基因控制，并与共病行为特征有关。最初，有选择地饲养大鼠以观察杏仁核点燃的速度，并在随后的世代中评估行为范式，以衡量活动、情绪性、冲动和学习。显然，点燃是受基因控制的，因为两种菌株被培育成对点燃快或慢，每一种都与不同的神经学、电生理和行为特征有关。在行为上，与慢鼠相比，快鼠看起来很像患有注意力缺陷多动障碍(ADHD)的人类，表现出容易分心、多动和冲动。
It was questioned whether amygdala kindling, a model of temporal lobe epilepsy, is under genetic control, and is associated with comorbid behavioral features. Initially, rats were selectively bred for speed of amygdala kindling, and, in subsequent generations, were assessed in behavioral paradigms to measure activity, emotionality, impulsivity, and learning. Clearly kindling was under genetic control, as two strains were developed to be either Fast or Slow to kindle, and each was associated with different neurological, electrophysiological and behavioral features. Behaviorally, the Fast rats appear much like humans with attention deficit hyperactivity disorder (ADHD), showing easy distraction, hyperactivity and impulsivity, compared to Slow rats.