Polymer gel dosimetry.
Polymer gel dosimetry.
复制标题
聚合物凝胶剂量测定。
DOI：
10.1088/0031-9155/55/5/r01
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发表时间：
2010-03-07
影响因子：
3.5
通讯作者：
Schreiner LJ
中科院分区：
文献类型：
--
作者：
Baldock C;De Deene Y;Doran S;Ibbott G;Jirasek A;Lepage M;McAuley KB;Oldham M;Schreiner LJ
聚合物凝胶剂量计由辐射敏感化学品制成，这些化学品在辐射后会根据吸收的辐射剂量发生聚合。这些凝胶剂量计能够独特地记录三维 (3D) 辐射剂量分布，与一维剂量计（例如电离室）和二维剂量计（例如胶片）相比，具有特定的优势。这些优点在存在陡峭剂量梯度的剂量测定情况下尤其重要，例如调强放射治疗 (IMRT) 和立体定向放射外科。聚合物凝胶剂量计对于近距离放射治疗剂量测定也具有特定的优势。潜在的剂量测定应用包括低能 X 射线、高线性能量转移 (LET) 和质子治疗、放射性核素和硼俘获中子治疗剂量测定。这些 3D 剂量计在放射学上与软组织等效，其属性可根据应用进行修改。聚合物凝胶剂量计中的 3D 辐射剂量分布可以使用磁共振成像 (MRI)、光学计算机断层扫描 (光学 CT)、X 射线 CT 或超声来成像。回顾了支撑聚合物凝胶剂量测定的基础科学以及各种评估技术。还介绍了聚合物凝胶剂量测定的临床剂量测定应用。
Polymer gel dosimeters are fabricated from radiation sensitive chemicals which, upon irradiation, polymerize as a function of the absorbed radiation dose. These gel dosimeters, with the capacity to uniquely record the radiation dose distribution in three-dimensions (3D), have specific advantages when compared to one-dimensional dosimeters, such as ion chambers, and two-dimensional dosimeters, such as film. These advantages are particularly significant in dosimetry situations where steep dose gradients exist such as in intensity-modulated radiation therapy (IMRT) and stereotactic radiosurgery. Polymer gel dosimeters also have specific advantages for brachytherapy dosimetry. Potential dosimetry applications include those for low-energy x-rays, high-linear energy transfer (LET) and proton therapy, radionuclide and boron capture neutron therapy dosimetries. These 3D dosimeters are radiologically soft-tissue equivalent with properties that may be modified depending on the application. The 3D radiation dose distribution in polymer gel dosimeters may be imaged using magnetic resonance imaging (MRI), optical-computerized tomography (optical-CT), x-ray CT or ultrasound. The fundamental science underpinning polymer gel dosimetry is reviewed along with the various evaluation techniques. Clinical dosimetry applications of polymer gel dosimetry are also presented.