Evidence for osteocyte regulation of bone homeostasis through RANKL expression
Evidence for osteocyte regulation of bone homeostasis through RANKL expression
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DOI：
10.1038/nm.2452
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发表时间：
2011-10-01
期刊：
影响因子：
82.9
通讯作者：
Takayanagi, Hiroshi
中科院分区：
文献类型：
--
作者：
Nakashima, Tomoki;Hayashi, Mikihito;Takayanagi, Hiroshi
嵌入骨中的骨细胞被认为通过调节成骨细胞和骨吸收破骨细胞来协调骨稳态。我们在这里发现纯化的骨细胞比成骨细胞和骨髓基质细胞表达更多的核因子- κ B配体受体激活因子（RANKL），并且具有更大的体外支持破骨细胞发生的能力。此外，我们在骨细胞特异性缺乏RANKL的小鼠中观察到严重的骨质疏松表型，这表明骨细胞是体内骨重塑中RANKL的主要来源。
Osteocytes embedded in bone have been postulated to orchestrate bone homeostasis by regulating both bone-forming osteoblasts and bone-resorbing osteoclasts. We find here that purified osteocytes express a much higher amount of receptor activator of nuclear factor-kappa B ligand (RANKL) and have a greater capacity to support osteoclastogenesis in vitro than osteoblasts and bone marrow stromal cells. Furthermore, the severe osteopetrotic phenotype that we observe in mice lacking RANKL specifically in osteocytes indicates that osteocytes are the major source of RANKL in bone remodeling in vivo.