Synthetic carbohydrate-based anticancer vaccines: the Memorial Sloan-Kettering experience.
Synthetic carbohydrate-based anticancer vaccines: the Memorial Sloan-Kettering experience.
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DOI：
10.1586/erv.09.95
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发表时间：
2009-10
影响因子：
6.2
通讯作者：
Danishefsky SJ
中科院分区：
文献类型：
--
作者：
Zhu J;Warren JD;Danishefsky SJ
Malignantly transformed cells can express aberrant cell surface glycosylation patterns, which serve to distinguish them from normal cells. This phenotype provides an opportunity for the development of carbohydrate-based vaccines for cancer immunotherapy. Synthetic carbohydrate-based vaccines, properly introduced through vaccination of a subject with a suitable construct, should be recognized by the immune system. Antibodies induced against these carbohydrate antigens could then participate in the eradication of carbohydrate-displaying tumor cells. Advances in carbohydrate synthetic capabilities have allowed us to efficiently prepare a range of complex, synthetic anticancer vaccine candidates. We describe herein the progression of our longstanding carbohydrate-based anticancer vaccine program, which is now at the threshold of clinical evaluation in several contexts. Our carbohydrate-based anticancer vaccine program has evolved through a number of stages: (1) monomeric vaccines; (2) monomeric clustered vaccines; (3) unimolecular multi-antigenic vaccines; (4) dual acting vaccines. This account will focus on our recently developed unimolecular multi-antigenic constructs and potential dual-acting constructs, which contain clusters of both carbohydrate and peptide epitopes.
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影响因子：
3.1
作者：
BARINGTON, T;GYHRS, A;HEILMANN, C
通讯作者：
HEILMANN, C
影响因子：
1.8
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Biswas, K;Coltart, DM;Danishefsky, SJ
通讯作者：
Danishefsky, SJ
影响因子：
15
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Allen, JR;Danishefsky, SJ
通讯作者：
Danishefsky, SJ
影响因子：
64.5
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Florman HM;Wassarman PM
通讯作者：
Wassarman PM
影响因子：
15
作者：
Glunz, PW;Hintermann, S;Danishefsky, SJ
通讯作者：
Danishefsky, SJ