Alcohol abuse and HIV infection: role of DRD2.
Alcohol abuse and HIV infection: role of DRD2.
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DOI：
10.2174/1570162x12666140721115045
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发表时间：
2014
影响因子：
1
通讯作者：
Nair M
中科院分区：
文献类型：
--
作者：
Agudelo M;Khatavkar P;Yndart A;Yoo C;Rosenberg R;Devieux JG;Malow RM;Nair M
根据艾滋病毒成本和服务利用研究 (HCSUS) 的一项调查，大约 53% 的艾滋病毒感染者报告饮酒，其中 8% 被归类为酗酒者。酒精作为 HIV 感染危险因素的作用已得到广泛研究，最近的研究发现，在感染 HIV 的酗酒者中，大量饮酒与 CD4 T 细胞水平较低之间存在显着关联。尽管有证据表明酒精是艾滋病毒传播和疾病进展的危险因素，但仍需要进行人群研究来确定影响酒精在艾滋病毒疾病进展中的作用的遗传机制。感兴趣的机制之一是多巴胺能系统。迄今为止，多巴胺对 HIV 神经免疫发病机制的影响尚不清楚。然而，已知艾滋病毒引起的多巴胺能神经变性是病毒通过免疫细胞侵入大脑而发生的，中枢神经系统中多巴胺的调节可能是不同类型的滥用物质影响艾滋病毒疾病进展的常见机制。尽管之前的研究表明 D(2) 多巴胺受体 (DRD2) 多态性与酒精依赖严重程度存在关联，但这种等位基因风险在酒精依赖 HIV 患者中的表达尚未得到系统探索。在当前的研究中，对 165 名感染 HIV 的酗酒者进行了 DRD2 Taq1A 和 C957T SNP 基因分型分析，并通过免疫状态和 CD4 计数检查了结果。
According to a survey from the HIV Cost and Services Utilization Study (HCSUS), approximately 53% of HIV-infected patients reported drinking alcohol and 8% were classified as heavy drinkers. The role of alcohol as a risk factor for HIV infection has been widely studied and recent research has found a significant association between heavy alcohol consumption and lower levels of CD4 T cells among HIV-infected alcoholics. Although there is evidence on the role of alcohol as a risk factor for HIV transmission and disease progression, there is a need for population studies to determine the genetic mechanisms that affect alcohol’s role in HIV disease progression. One of the mechanisms of interest is the dopaminergic system. To date, the effects of dopamine on HIV neuroimmune pathogenesis are not well understood; however, dopaminergic neural degeneration due to HIV is known to occur by viral invasion into the brain via immune cells, and modulation of dopamine in the CNS may be a common mechanism by which different types of substances of abuse impact HIV disease progression. Although previous studies have shown an association of D(2) dopamine receptor (DRD2) polymorphisms with severity of alcohol dependence, the expression of this allele risk on HIV patients with alcohol dependence has not been systematically explored. In the current study, DRD2 Taq1A and C957T SNP genotyping analyses were performed in 165 HIV-infected alcohol abusers and the results were examined with immune status and CD4 counts.