Reduced tumor growth with combined radiofrequency ablation and radiation therapy in a rat breast tumor model
Reduced tumor growth with combined radiofrequency ablation and radiation therapy in a rat breast tumor model
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DOI：
10.1148/radiol.2351040269
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发表时间：
2005-04-01
期刊：
影响因子：
19.7
通讯作者：
Goldberg, SN
中科院分区：
文献类型：
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作者：
Horkan, C;Dalal, K;Goldberg, SN
目得：在动物肿瘤模型中，确定联合射频消融和外照射治疗是否能增加终点生存率，超过单独射频消融或放射治疗。材料和方法：根据机构动物护理和使用委员会批准的方案，将R3230乳腺癌（12.5 mm +/- 0.6 [标准差]）皮下植入107只雌性Fischer 344大鼠。最初，将42个肿瘤随机分为四个治疗组：（a）单独射频消融（70 ℃，5分钟），（B）射频消融后进行放射治疗，（c）单独20-戈伊放射，（d）不治疗。另一组总剂量为20戈伊，19个肿瘤随机接受（e）射频消融（70 ℃，5分钟），随后接受5-戈伊辐射，（0 - 5-戈伊辐射单独治疗，或（g）不治疗。对动物进行随访直至存活终点（直至肿瘤生长至直径30 mm，或者如果在乳房脂肪垫或胸壁中未观察到肿瘤，则持续120天）。结果采用Kaplan-Meier法进行分析。在生存终点时对另外15个肿瘤进行组织学分析，在其他特定终点时对另外18个代表性肿瘤进行组织学分析。联合射频消融和20-戈伊辐射导致11个肿瘤中的9个（82%）完全局部控制，与之相比，11例单纯射频消融治疗的肿瘤中有1例（9%），6例射频消融加5-戈伊放疗的肿瘤中有1例（17%）（P <0.001）。在单独使用放射治疗的大鼠或对照组中未实现局部控制。对照组的中位终点生存期为12天，射频消融或单独5-戈伊放疗组为20天，射频消融加5-戈伊放疗组为30天，单独20-戈伊放疗组为40天，射频消融加20-戈伊放疗组为120天。对照组的平均终点生存期为13天5（标准差），单独射频消融组为34天31，单独20-戈伊照射组为43天16。20-戈伊放疗和射频消融联合治疗组的平均生存期显著延长：94天34天（与所有其他组相比，P <0.001）。接受5-戈伊辐射与射频消融与没有大鼠的平均生存期分别为46天37与24天11.CONCLUSION：联合射频消融和外束放射治疗增加动物生存率与单独或没有治疗的治疗相比。(C)RSNA 2005年。
PURPOSE: To determine whether use of combined radiofrequency (RF) ablation and external-beam radiation therapy increases end-point survival beyond that with either RF ablation or radiation therapy alone in an animal tumor model.MATERIALS AND METHODS: With a protocol approved by the institutional animal care and use committee, R3230 mammary adenocarcinoma (12.5 mm +/- 0.6 [standard deviation]) was implanted subcutaneously into 107 female Fischer 344 rats. Initially, 42 tumors were randomized into four treatment groups: (a) RF ablation (70 degrees C for 5 minutes) alone, (b) RF ablation followed by radiation therapy (c) 20-Gy radiation alone, and (d) no treatment. Another with a total dose of 20 Gy, 19 tumors were randomized to receive (e) RF ablation (70 degrees C for 5 minutes) followed by 5-Gy radiation, (0 5-Gy radiation alone, or (g) no treatment. Animals were followed up until survival end point (either until tumor growth to 30 mm in diameter, or for 120 days if no tumor was seen in mammary fat pad or chest wall). Results were analyzed with the Kaplan-Meier method. Histopathologic analysis was performed in 15 additional tumors at survival end point and 18 other representative tumors at other specified end points.RESULTS: Combined RF ablation and 20-Gy radiation resulted in complete local control in nine (82%) of 11 tumors, compared with one (9%) of 11 tumors treated with RF ablation alone and one (17%) of six treated with RF ablation and 5-Gy radiation (P < .001). No local control was achieved in rats with radiation therapy alone or in controls. Median end-point survival was 12 days for controls, 20 days with RF ablation or 5-Gy radiation alone, 30 days with RF ablation plus 5-Gy radiation, 40 days with 20-Gy radiation alone, and 120 days with RF ablation plus 20-Gy radiation. Mean end-point survival was 13 days 5 (standard deviation) for the control group, 34 days 31 with RF ablation alone, and 43 days 16 with 20-Gy radiation alone. Mean survival was significantly greater with 20-Gy radiation and RF ablation combined: 94 days 34 (P < .001 compared with all other groups). Mean survival for rats that received 5-Gy radiation with RF ablation versus without was 46 days 37 versus 24 days 11, respectively.CONCLUSION: Combined RF ablation and external-beam radiation therapy increased animal survival compared with that with either of the treatments alone or with no treatment. (C) RSNA 2005.