EXTRACELLULAR-MATRIX IN TESTICULAR-DIFFERENTIATION
EXTRACELLULAR-MATRIX IN TESTICULAR-DIFFERENTIATION
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DOI：
10.1111/j.1749-6632.1984.tb38302.x
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发表时间：
1984-01-01
影响因子：
5.2
通讯作者：
LAKKALAPARANKO, T
中科院分区：
文献类型：
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作者：
PELLINIEMI, LJ;PARANKO, J;LAKKALAPARANKO, T
在性冷淡性腺形成睾丸的关键和决定性事件是上皮性睾丸索的组织。“无性腺由组织学上无组织的髓质性腺囊胚和层状表面上皮皮层组成，在某些地方与髓质囊胚连续。”*上皮索形成起始的最早迹象是相邻细胞通过质膜附着和基底膜样物质沿着未来的基底表面的出现。自从Wachtel等人引入关于睾丸索形成机制的HY理论以来，细胞表面事件在感兴趣的研究者中得到了最多的关注。然而，上皮不仅仅是由特定细胞的紧密相互粘附所定义的，而是由基膜的产生作为与周围组织的物理化学屏障所定义的。因此，任何涉及上皮组织的调节因子都必须考虑到这些事件中的一个或两个。颞
The crucial and definitive event in the formation of a testis from a sexually indifferent gonad is the organization of epithelial testicular cords.'The indifferent gonad consists of histologically unorganized gonadal blastema in the medulla and a cortex of stratified surface epithelium, which at places is continuous with the medullary blastema.'.* The earliest signs of the initiation of epithelial cord formation are the attachment of adjacent cells by plasma membrane apposition and the appearance of basement membrane-like material along the future basal surface of the Ever since the introduction of the HY theory about the mechanisms of the testis cord formation by Wachtel et al. 4 the cell surface events have received the most attention among the interested investigators.'.'However, an epithelium is not only defined by close mutual adherence of particular cells but rather by production of a basement membrane as a physicochemical barrier against the surrounding tissue. Any regulatory factor involved in the epithelial organization must therefore account for one or both of these events. The temporal