Multiple cell type-specific proteins differentially regulate target sequence recognition by the α retinoic acid receptor
Multiple cell type-specific proteins differentially regulate target sequence recognition by the α retinoic acid receptor
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多种细胞类型特异性蛋白质差异调节α视黄酸受体的靶序列识别
DOI：
10.1016/0092-8674(90)90139-6
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发表时间：
1990
期刊：
影响因子：
64.5
通讯作者：
M. Rosenfeld
中科院分区：
文献类型：
--
作者：
C. Glass;O. Devary;M. Rosenfeld
视黄酸受体通过调节不同细胞类型中不同靶基因的转录，对脊椎动物的发育产生深远的影响。几条线的证据是存在多个，细胞类型特异性的核蛋白，其功能差异增加的各种响应元素的视黄酸受体的结合亲和力。这些蛋白质，我们称之为视黄酸受体辅助调节因子，通过与其配体结合结构域重叠的共同二聚化界面与视黄酸受体相互作用。这些观察结果提出了有趣的可能性，辅助调节蛋白的作用是限制和/或直接影响维甲酸受体的基因表达模式在发展过程中。
Retinoic acid receptors appear to exert profound effects on vertebrate development by regulating the transcription of distinct sets of target genes within different cell types. Several lines of evidence are presented for the existence of multiple, cell type-specific nuclear proteins that function to differentially increase the binding affinity of the a retinoic acid receptor for a variety of response elements. These proteins, which we refer to as retinoic acid receptor coregulators, interact with the retinoic acid receptor via a common dimerization interface that overlaps with its ligand binding domain. These observations raise the intriguing possibility that coregulator proteins serve to restrict and/or direct the effects of retinoic acid receptors on patterns of gene expression during development.
DOI：
10.1073/pnas.86.23.9099
发表时间：
1989-12
影响因子：
11.1
作者：
George W. Vasios;Joseph D. Gold;M. Petkovich;P. Chambon;L. Gudas
通讯作者：
George W. Vasios;Joseph D. Gold;M. Petkovich;P. Chambon;L. Gudas
鉴定增强甲状腺激素受体与甲状腺激素反应元件结合的核因子。
DOI：
10.1210/mend-3-9-1434
发表时间：
1989
期刊：
Molecular endocrinology (Baltimore, Md.)
影响因子：
--
作者：
Murray,MB;Towle,HC
通讯作者：
Towle,HC