Periodontal ligament fibroblasts, preosteoblasts, and prechondrocytes express receptors for epidermal growth factor in vivo: a comparative radioautographic study.
Periodontal ligament fibroblasts, preosteoblasts, and prechondrocytes express receptors for epidermal growth factor in vivo: a comparative radioautographic study.
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牙周膜成纤维细胞、前成骨细胞和前软骨细胞在体内表达表皮生长因子受体：一项比较放射自显影研究。
DOI：
10.1111/j.1600-0765.1988.tb01419.x
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发表时间：
1988
影响因子：
3.5
通讯作者：
Lee,YL
中科院分区：
文献类型：
--
作者：
Cho,MI;Garant,PR;Lee,YL
用放射性碘标记的小鼠表皮生长因子（EGF），在光镜和电镜下研究EGF与幼鼠各种细胞的结合。牙周膜成纤维细胞、前成骨细胞和前软骨细胞上有高水平的结合EGF。口腔粘膜、尾上皮下结缔组织和尾腱中的成纤维细胞表现出低得多的结合水平。超微结构放射自显影显示，银颗粒，指示放射性碘标记的EGF，在注射生长因子后5分钟位于细胞质膜附近或上方。牙周膜成纤维细胞上高水平EGF受体的意义，与前骨细胞和前软骨细胞上观察到的数量相当，讨论了牙周膜成纤维细胞对邻近硬组织产生细胞的可能祖细胞作用。
Radioiodinated mouse epidermal growth factor (EGF) was used in light and electron microscopic radioautographic studies of the binding of EGF to various cells of young rats. High levels of bound EGF were noted on periodontal ligament fibroblasts, preosteoblasts, and prechondrocytes. Fibroblast in the oral mucosa, tail subepithelial connective tissue, and tail tendon demonstrated much lower levels of binding. Ultrastructural radioautography revealed that silver grains, indicative of radioiodinated EGF, were positioned adjacent to or over the plasma membranes of the cells at 5 minutes after injection of the growth factor. The significance of the high level of EGF receptors on periodontal ligament fibroblasts, comparable to the number observed on preosteocytes and prechondrocytes, is discussed in terms of the possible progenitor role of periodontal ligament fibroblasts for adjacent hard tissue‐producing cells.