Clinicopathological features of radiological early malignant pleural mesothelioma with no apparent tumor or pleural thickening
Clinicopathological features of radiological early malignant pleural mesothelioma with no apparent tumor or pleural thickening
复制标题
无明显肿瘤或胸膜增厚的早期恶性胸膜间皮瘤的放射学临床病理特征
DOI：
10.1007/s10147-020-01780-0
复制
发表时间：
2020
影响因子：
3.3
通讯作者：
Hasegawa Seiki
中科院分区：
文献类型：
--
作者：
Nakamura Akifumi;Hashimoto Masaki;Kodama Hiroshi;Yuki Michiko;Kondo Nobuyuki;Yamakado Koichiro;Tsujimura Tohru;Kijima Takashi;Hasegawa Seiki
我们偶尔会遇到恶性胸膜间皮瘤（MPM），没有明显的肿瘤或胸膜增厚，这是放射学上的早期MPM。本研究旨在探讨放射学早期MPM的临床病理结果。方法回顾性分析2004年7月至2019年12月诊断时接受新辅助化疗和计划手术治疗的MPM患者。在胸部计算机断层扫描上测量所有患者的最大胸膜厚度。我们提取并研究了没有胸膜增厚或可见肿瘤的患者，这些患者被定义为放射学早期MPM。采用Kaplan-Meier法分析生存率。结果296例患者中，16例（5.4%）表现为放射学早期MPM。其中14例（87.5%）行胸膜切除术/去皮术，2例（12.5%）行胸膜外全肺切除术。病理T1期疾病14例（87.5%）；2例（12.5%）表现为肺实质侵犯（病理分期T2）。仅1例患者有淋巴浸润。未发现淋巴结转移和血管侵犯。中位随访时间为42个月。中位无进展生存期和中位总生存期分别为40.7个月和56.1个月。3年无进展生存率和总生存率分别为84.8%和83.6%。结论：在经验丰富的中心诊断时，每20例接受新辅助化疗和计划手术的患者中约有1例发生放射学早期MPM。放射学早期MPM与早期病理分期和长期生存相关。
BackgroundWe occasionally encounter malignant pleural mesothelioma (MPM) of no apparent tumor or pleural thickening that is radiological early MPM. This study aimed to examine the clinicopathological outcomes of radiological early MPM.MethodsPatients with MPM treated with neoadjuvant chemotherapy and planned surgery at the time of diagnosis between July 2004 and December 2019 were retrospectively examined. Pretreatment maximal pleural thickness of all patients was measured on chest computed tomography. We extracted and investigated the patients who exhibited a lack of pleural thickening or visible tumor, which was defined as radiological early MPM. Survival was analyzed by the Kaplan–Meier method.ResultsOf 296treated patients, 16 (5.4%) exhibited radiological early MPM. Fourteen (87.5%) of these patients underwent pleurectomy/decortication and 2 (12.5%) underwent extrapleural pneumonectomy. Pathological stage T1 disease was diagnosed in 14 (87.5%) patients; 2 (12.5%) exhibited pulmonary parenchymal invasion (pathological stage T2). Lymphatic invasion was detected in only 1 patient. Lymph node metastases and vascular invasion were not detected. Median follow-up was 42 months. Median progression-free survival and median overall survival were 40.7 and 56.1 months, respectively. The 3-year progression-free survival and overall survival rates were 84.8% and 83.6%, respectively.ConclusionsRadiological early MPM occurs in approximately 1 of every 20 patients treated with neoadjuvant chemotherapy and surgery planned at the time of diagnosis in an experienced center. Radiological early MPM was associated with early pathological stage and long-term survival.
登录
查看更多内容
使用计算机断层扫描识别结核引起的疤痕癌及其与组织学的相关性
DOI：
--
发表时间：
2007
期刊：
--
影响因子：
--
作者：
H. Viljoen;G. Cilliers;C. Ackermann;S. Andronikou
通讯作者：
S. Andronikou
IASLC 间皮瘤分期项目的教员意见建议：对即将发布的第八版胸膜间皮瘤 TNM 分类中的 N 描述符进行修订的建议。
DOI：
10.3410/f.726791524.793551904
发表时间：
2018
期刊：
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
影响因子：
--
作者：
P. V. Van Schil
通讯作者：
P. V. Van Schil
影响因子：
20.4
作者：
Nowak, Anna K.;Chansky, Kari;Rusch, Valerie W.
通讯作者：
Rusch, Valerie W.
影响因子：
3.3
作者：
Seely, Jean M.;Nguyen, Elsie T.;Mueller, Nestor L.
通讯作者：
Mueller, Nestor L.
DOI：
10.1053/j.semtcvs.2019.01.010
发表时间：
2019-06-01
影响因子：
2.5
作者：
Hasegawa, Seiki;Kondo, Nobuyuki;Nakano, Takashi
通讯作者：
Nakano, Takashi