VACCINIA VIRUS ENCODES A POLYPEPTIDE HOMOLOGOUS TO EPIDERMAL GROWTH-FACTOR AND TRANSFORMING GROWTH-FACTOR
VACCINIA VIRUS ENCODES A POLYPEPTIDE HOMOLOGOUS TO EPIDERMAL GROWTH-FACTOR AND TRANSFORMING GROWTH-FACTOR
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DOI：
10.1038/313491a0
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发表时间：
1985-01-01
期刊：
影响因子：
64.8
通讯作者：
TODARO, GJ
中科院分区：
文献类型：
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作者：
BROWN, JP;TWARDZIK, DR;TODARO, GJ
表皮生长因子（EGF）和转化生长因子I型（TGF）分别是53和50个氨基酸残基的多肽1，2。两者均与EGF受体（一种1，200个残基的跨膜糖蛋白3）结合，导致受体磷酸化，增强其酪氨酸特异性激酶活性，并最终刺激细胞生长4，5。本文报道了痘苗病毒（VV）60早期基因编码的一个140个氨基酸残基的多肽与EGF和TGF密切相关。假定的信号和跨膜序列的存在进一步表明，病毒蛋白可能是一个完整的膜蛋白，但在EGF本身的情况下，膜相关的形式可能是可溶性生长因子的前体。由病毒感染的细胞产生EGF样生长因子可以解释与痘病毒家族成员相关的增殖性疾病，如Shope纤维瘤病毒9、Yaba肿瘤病毒10和传染性软疣病毒（MCV）11。
Epidermal growth factor (EGF) and transforming growth factor type I (TGF) are polypeptides of 53 and 50 amino acid residues, respectively1,2. Both bind to EGF receptor, a 1,200-residue transmembranous glycoprotein3, leading to phosphorylation of the receptor, enhancement of its tyrosine-specific kinase activity and ultimately to stimulation of cell growth4,5. We report here that a 140-residue polypeptide encoded by one of the early genes of vaccinia virus (VV)6is related closely to EGF and TGF. The presence of putative signal and transmembranous sequences further suggests that the viral protein might be an integral membrane protein, but that, as in the case of EGF itself7,8, the membrane-associated form may be the precursor of a soluble growth factor. Production of EGF-like growth factors by virally infected cells could account for the proliferative diseases associated with members of the poxvirus family such as Shope fibroma virus9, Yaba tumour virus10, and molluscum contagiosum virus (MCV)11.