A separate disease within the syndrome of schizophrenia
A separate disease within the syndrome of schizophrenia
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DOI：
10.1001/archpsyc.58.2.165
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发表时间：
2001-02-01
影响因子：
--
通讯作者：
Carpenter, WT
中科院分区：
文献类型：
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作者：
Kirkpatrick, B;Buchanan, RW;Carpenter, WT
如果精神分裂症是一种临床综合征而不是一种单一的疾病，那么在综合征中识别出特定的疾病将有助于知识的进步和更具体治疗方法的发展。我们提出，缺陷精神病理学（即持久的特发性阴性症状）定义了一组与精神分裂症不同的疾病患者，这些患者没有缺陷特征，因为缺陷组和非缺陷组在体征和症状、病程、生物学相关因素、治疗反应和病因学因素方面存在差异。这些差异不能归因于缺陷组中更严重的阳性精神病症状或更长的疾病持续时间。另一种解释，即缺陷型精神分裂症患者是在一个单一的疾病连续体的严重结束是不支持的危险因素和生物学特征的数据，但有必要独立复制这些结果。我们建议进行一系列的研究，旨在证明这些假设之一，即多种疾病与单一疾病。
If schizophrenia is a clinical syndrome rather than a single disease, the identification of specific diseases within the syndrome would facilitate the advance of knowledge and the development of more specific treatments. We propose that deficit psychopathology tie, enduring, idiopathic negative symptoms) defines a group of patients with a disease different from schizophrenia without deficit features, as the deficit and nondeficit groups differ in their signs and symptoms, course, biological correlates, treatment response, and etiologic factors. These differences cannot be attributed to more severe positive psychotic symptoms or a greater duration of illness in the deficit group. The alternative interpretation that patients with deficit schizophrenia are at the severe end of a single disease continuum is not supported by risk factor and biological features data, but there is a need for independent replication of these findings. We suggest a series of studies designed to falsify one of these hypotheses, ie, multiple diseases vs a single disease.