Apolipoprotein E polymorphism in men and women from a Spanish population:: allele frequencies and influence on plasma lipids and apolipoproteins
Apolipoprotein E polymorphism in men and women from a Spanish population:: allele frequencies and influence on plasma lipids and apolipoproteins
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DOI：
10.1016/s0021-9150(99)00168-9
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发表时间：
1999-11-01
期刊：
影响因子：
5.3
通讯作者：
Lasunción, MA
中科院分区：
文献类型：
--
作者：
Gómez-Coronado, D;Alvarez, JJ;Lasunción, MA
在西班牙马德里的工作人群中测定了男性和女性的载脂蛋白（apo）E表型及其对血脂和载脂蛋白水平的影响。在研究人群（n = 614）中，等位基因E12、E13和E14的相对频率分别为0.080、0.842和0.078。在男性中，载脂蛋白E多态性与血浆甘油三酯和极低密度脂蛋白（VLDL）脂质水平的变化相关。它与载脂蛋白C-Ⅱ在VLDL中的比例有关，并解释了后者参数的5.5%的变异性。女性载脂蛋白E基因多态性与血浆胆固醇、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）浓度相关。以等位基因F13纯合性为参照，分析等位基因效应。在男性中，等位基因E12显著增加极低密度脂蛋白甘油三酯和极低密度脂蛋白胆固醇浓度，这是伴随着这些颗粒中的载脂蛋白C-II含量的增加。等位基因E14对男性的脂蛋白没有任何显着影响。在女性中，等位基因2降低LDL胆固醇和载脂蛋白B水平，而等位基因4增加LDL胆固醇，降低HDL胆固醇、HDL磷脂和载脂蛋白A-I的浓度。在将绝经后妇女和口服避孕药使用者从分析中排除后，这些影响基本上保持不变。最后总结：（1）与其他地中海地区人群相似，马德里人群的载脂蛋白E4表达低于高加索人的平均患病率，（2）性别与载脂蛋白E多态性的影响相互作用：在女性中，它影响LDL和HDL水平，而在男性中，它优先影响VLDL，和（3）等位基因R12降低女性的LDL水平，而在男性中，它增加了VLDL脂质水平和apo C-II含量，但与等位基因E4相反，它在两性中均未显示对HDL的影响。(C)1999爱思唯尔科学爱尔兰有限公司保留所有权利。
The apolipoprotein (apo)E phenotype and its influence on plasma lipid and apolipoprotein levels were determined in men and women from a working population of Madrid, Spain. The relative frequencies of alleles epsilon 2, epsilon 3 and epsilon 4 for the study population (n = 614) were 0.080, 0.842 and 0.078, respectively. In men, apo E polymorphism was associated with variations in plasma triglyceride and very low-density lipoprotein (VLDL) lipid levels. It was associated with the proportion of apo C-II in VLDL, and explained 5.5% of the variability in the latter parameter. In women apo E polymorphism was associated with the concentrations of plasma cholesterol and low-density lipoprotein (LDL) and high-density lipoprotein (HDL) related variables. The allelic effects were examined taking allele epsilon 3 homozygosity as reference. In men, allele epsilon 2 significantly increased VLDL triglyceride and VLDL cholesterol concentrations, and this was accompanied by an increase of the apo C-II content in these particles. Allele epsilon 4 did not show any significant influence on men's lipoproteins. In women, allele epsilon 2 lowered LDL cholesterol and apo B levels, while allele epsilon 4 increased LDL cholesterol and decreased the concentrations of HDL cholesterol, HDL phospholipid and apo A-I. These effects were essentially maintained after excluding postmenopausal women and oral contraceptive users from the analysis. In conclusion: (1) the population of Madrid, similar to other Mediterranean populations, exhibits an underexpression of apo E4 compared to the average prevalence in Caucasians, (2) gender interacts with the effects of apo E polymorphism: in women, it influenced LDL and HDL levels, whereas in men it preferentially affected VLDL, and (3) allele epsilon 2 decreased LDL levels in women, while it increased both VLDL lipid levels and apo C-II content iri men, but, in contrast to allele E4, it did not show an impact on HDL in either sex. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.