Hierarchical Organization of Scripts: Converging Evidence from fMRI and Frontotemporal Degeneration
Hierarchical Organization of Scripts: Converging Evidence from fMRI and Frontotemporal Degeneration
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DOI：
10.1093/cercor/bhp313
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发表时间：
2010-10-01
期刊：
影响因子：
3.7
通讯作者：
Grossman, Murray
中科院分区：
文献类型：
--
作者：
Farag, Christine;Troiani, Vanessa;Grossman, Murray
本研究检查了复杂的熟悉活动的组织，称为“脚本”（例如，“钓鱼”）。我们评估了脚本中的事件是否以线性顺序方式或聚类分层方式处理，并评估了这种处理能力的神经基础。从健康年轻人的功能性神经影像学和局灶性神经退行性疾病患者的行为和结构磁共振成像（MRI）数据中获得了一致的证据。在这两项研究中，参与者判断从脚本中提取的连续事件对的顺序。事件对要么在脚本中聚集在一起，要么来自脚本中的不同集群。控制判断事件更准确，更快，如果从同一个集群内的脚本相比，不同的集群，即使所有的事件对是连续的，与脚本的层次结构一致。功能性磁共振成像与双侧下额叶激活相关。进行性非流利性失语症或行为变异性额颞叶痴呆患者不能区分脚本中同一簇或不同簇的事件对。结构性MRI将这种缺陷与显著的额叶皮质萎缩相关联。我们的研究结果表明，额叶皮层有助于在脚本理解聚类事件，强调了额叶皮层在脚本的层次组织的作用。
The present study examined the organization of complex familiar activities, known as "scripts" (e.g., "going fishing"). We assessed whether events in a script are processed in a linear-sequential manner or clustered-hierarchical manner, and we evaluated the neural basis for this processing capacity. Converging evidence was obtained from functional neuroimaging in healthy young adults and from behavioral and structural magnetic resonance imaging (MRI) data in patients with focal neurodegenerative disease. In both studies, participants judged the order of consecutive event pairs taken from a script. Event pairs either were clustered together within a script or were from different clusters within the script. Controls judged events more accurately and quickly if taken from the same cluster within a script compared with different clusters, even though all event pairs were consecutive, consistent with the hierarchical organization of a script. Functional magnetic resonance imaging associated this with bilateral inferior frontal activation. Patients with progressive nonfluent aphasia or behavior-variant frontotemporal dementia did not distinguish between event pairs from the same cluster or from different clusters within a script. Structural MRI associated this deficit with significant frontal cortical atrophy. Our findings suggest that frontal cortex contributes to clustering events during script comprehension, underlining the role of frontal cortex in the hierarchical organization of a script.