Influence of Mycobacterium bovis bacillus Calmette-Guerin on antibody and cytokine responses to human neonatal vaccination
Influence of Mycobacterium bovis bacillus Calmette-Guerin on antibody and cytokine responses to human neonatal vaccination
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DOI：
10.4049/jimmunol.168.2.919
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发表时间：
2002-01-15
影响因子：
4.4
通讯作者：
Marchant, A
中科院分区：
文献类型：
--
作者：
Ota, MOC;Vekemans, J;Marchant, A
免疫系统的不成熟增加了幼儿对传染病的易感性，并阻止疫苗诱导保护性免疫反应。我们之前报道过，新生儿接种牛分枝杆菌卡介苗（BCG）可诱导对分枝杆菌Ags产生强效Th1应答。在这项研究中，我们评估了卡介苗对早期接种的不相关疫苗的反应的影响。新生儿被随机分配到三个研究组中的一个，在出生时接受卡介苗，当婴儿接受第一剂乙型肝炎和口服脊髓灰质炎疫苗时；2个月大时，婴儿接种第一剂白喉和破伤风疫苗；或者在4.5月龄时，对疫苗的免疫反应进行测量。接种时接种卡介苗可显著提高乙肝疫苗的细胞和抗体应答，但对细胞因子对破伤风类毒素的应答影响有限，对破伤风和白喉类毒素的抗体应答无影响。虽然卡介苗诱导了对分枝杆菌Ags的强效Th1型反应，但它促进了对不相关疫苗的Th1型和th2型细胞因子的产生。卡介苗的作用在全身水平上是明显的，因为它增加了对口服脊髓灰质炎疫苗的抗体反应。这些结果表明，卡介苗可能通过影响树突状细胞的成熟，影响生命早期对不相关Ags的免疫反应。
The immaturity of the immune system increases the susceptibility of young infants to infectious diseases and prevents the induction of protective immune responses by vaccines. We previously reported that Mycobacterium bovis bacillus Calmette-Guerin (BCG) vaccination induces a potent Th1 response to mycobacterial Ags in newborns. In this study, we evaluated the influence of BCG on the response to unrelated vaccines given in early life. Newborns were randomly allocated to one of three study groups receiving BCG at birth, when infants received their first dose of hepatitis B and oral polio vaccines; at 2 mo of age, when infants received their first dose of diphtheria and tetanus vaccines; or at 4.5 mo of age, when immune responses to vaccines were measured. Administration of BCG at the time of priming markedly increased the cellular and Ab responses to the hepatitis B vaccine, but had only a limited influence on the cytokine response to tetanus toxoid and no effect on the Ab responses to tetanus and diphtheria toxoids. Although BCG induced a potent Th1-type response to mycobacterial Ags, it promoted the production of both Th1- and Th2-type cytokines in response to unrelated vaccines. The effect of BCG was apparent at the systemic level, as it increased the Ab response to oral polio vaccine. These results demonstrate that BCG influences the immune response to unrelated Ags in early life, likely through its influence on the maturation of dendritic cells.