THE MICROTUBULE CYTOSKELETON AND THE DEVELOPMENT OF NEURONAL POLARITY
THE MICROTUBULE CYTOSKELETON AND THE DEVELOPMENT OF NEURONAL POLARITY
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DOI：
10.1016/0197-4580(94)00164-v
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发表时间：
1995-05-01
影响因子：
4.2
通讯作者：
BANKER, GA
中科院分区：
文献类型：
--
作者：
MANDELL, JW;BANKER, GA
轴突和树突代表神经细胞的基本极化的概念已经被许多形态学、功能和分子研究所证实。极性是如何在发育过程中产生的？我们和其他人一直关注微管细胞骨架的作用，因为微管（a）是轴突和树突的重要组成部分;（B）在分子水平上具有固有的极性;（c）通过与微管相关蛋白（MAP）的相互作用进行调节，其中一些在成熟神经元中具有极化分布。在这里，我们审查数据的初始收购的极性观察到在神经元的培养和微管和地图在这一形态发生事件中的作用。我们目前的数据澄清了一些以前相互矛盾的结果，在建立极性的tau定位，并提供了新的证据，tau的磷酸化在空间上调节的极性在文化的发展。阐明在正常神经元发育过程中局部调节tau蛋白磷酸化的机制，可能是由于其异常磷酸化在阿尔茨海默病中的意义。
The concept that axons and dendrites represent a fundamental polarization of the nerve cell has been borne out by numerous morphological, functional, and molecular studies. How does polarity arise during development? We and others have focused on the role of the microtubule cytoskeleton because microtubules (a) are essential components of axons and dendrites; (b) possess an inherent polarity at the molecular level; (c) are regulated by interactions with microtubule associated proteins (MAPs), some of which have polarized distributions in mature neurons. Here we review data on the initial acquisition of polarity as observed in neuronal culture and roles for microtubules and MAPs in this morphogenetic event. We present data clarifying some previously conflicting results on tau localization during the establishment of polarity and provide new evidence that phosphorylation of tau is spatially regulated during the development of polarity in culture. Elucidation of mechanisms locally regulating tau phosphorylation during normal neuronal development may provide dues to the significance of its abnormal phosphorylation in Alzheimer's disease.