Body mass index trajectories in pediatric multiple sclerosis
Body mass index trajectories in pediatric multiple sclerosis
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DOI：
10.1111/dmcn.14233
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发表时间：
2019-11-01
影响因子：
3.8
通讯作者：
Goldman, Myla D.
中科院分区：
文献类型：
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作者：
Brenton, J. Nicholas;Woolbright, Emma;Goldman, Myla D.
目的描述多发性硬化症儿童的生长轨迹，并与典型的发展中地区同龄人和疾病控制中心（CDC）的标准值进行比较。方法本病例对照研究收集了40例多发性硬化症患儿（女28例，男12例）的体重、身高和身体质量指数（BMI），以及120例典型发育的同龄人（女84例，男36例），确定并匹配出生年份、性别、种族和社会经济地位。根据CDC参考值，将BMI值转换为z评分，并比较两个队列之间的年龄和病例相对于多发性硬化症发作的年龄。结果多发性硬化临床发病的中位年龄为15岁。多发性硬化症患者的BMI z评分显著高于典型发展中的人口统计学匹配的同龄人和CDC标准。BMI的这些显著差异从4岁及以上开始观察。病例组和对照组的身高轨迹和CDC标准值相似。儿童多发性硬化症的BMI明显较高，从儿童早期开始，在疾病临床发作前几年。这篇论文补充说，在诊断时，患有多发性硬化症的儿童比正常发育的同龄人明显超重。在多发性硬化症临床表现之前的几年，体重指数轨迹显著较高。
Aim To characterize growth trajectories of children who develop multiple sclerosis compared to typically developing, regional peers and Centers for Disease Control (CDC) normative values. Method This case-control study collected weight, height, and body mass index (BMI) in 40 consecutive pediatric patients with multiple sclerosis (28 females, 12 males), in addition to 120 typically developing peers (84 females, 36 males), identified and matched for year of birth, sex, ethnicity, and socio-economic status. BMI values were converted to z-scores based on CDC reference values and were compared with respect to age between our two cohorts and by years relative to multiple sclerosis onset for cases. Results Median age for the clinical onset of multiple sclerosis was 15 years. BMI z-scores are significantly higher for patients with multiple sclerosis compared to typically developing, demographically-matched peers and CDC standards. These significant differences in BMI are noted from 4 years of age and onward. Height trajectories were similar among case and control individuals and CDC normative values. Interpretation BMI in pediatric multiple sclerosis is markedly higher, beginning in early childhood, years before the clinical-onset of the disease. What this paper addsChildren with multiple sclerosis are significantly more overweight than typically developing peers at the time of diagnosis. Body mass index trajectories are significantly higher years before the clinical manifestation(s) of multiple sclerosis.