Human immunodeficiency virus infection and female lower genital tract malignancy.
Human immunodeficiency virus infection and female lower genital tract malignancy.
复制标题
人类免疫缺陷病毒感染与女性下生殖道恶性肿瘤。
DOI：
10.1097/00001703-199901000-00007
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发表时间：
1999
影响因子：
2.1
通讯作者：
T. Wright
中科院分区：
文献类型：
--
作者：
L. Kuhn;Xiao Wei Sun;T. Wright
感染艾滋病毒的妇女患下生殖道肿瘤的风险增加。这在宫颈鳞状上皮内病变中得到了最好的证明，但在一些研究中也发现了外阴和肛周上皮内病变。下生殖道人类乳头瘤病毒感染的流行率和自然史的改变似乎是增加的主要原因。感染艾滋病毒的妇女感染人乳头瘤病毒（包括感染致癌风险高的人乳头瘤病毒类型）的可能性大约是未感染艾滋病毒的妇女的四倍，而且这些感染更有可能持续存在。人乳头瘤病毒相关病变在感染艾滋病毒的妇女中可能更难治疗。这些数据突出表明，需要为感染艾滋病毒的妇女制定有效的宫颈癌预防方案。
The risk of lower genital tract neoplasia is increased in women infected with HIV. This has been best demonstrated in cervical squamous intraepithelial lesions, but has also been observed in vulvar and perianal intraepithelial lesions in some studies. Alterations in the prevalence and natural history of human papillomavirus infections of the lower genital tract appear to account for much of the increase. HIV-infected women are approximately four times more likely to be infected with human papillomavirus (including infection with high oncogenic risk human papillomavirus types) than are HIV-uninfected women, and these infections are more likely to be persistent. Human papilomavirus-associated lesions may be more difficult to treat in HIV-infected women. These data highlight the need to develop effective cervical cancer prevention programs for HIV-infected women.