Adsorption of ionized and neutral pentachlorophenol to phosphatidylcholine membranes.
Adsorption of ionized and neutral pentachlorophenol to phosphatidylcholine membranes.
复制标题
离子化和中性五氯苯酚对磷脂酰胆碱膜的吸附。
DOI：
10.1016/0005-2736(87)90025-3
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Barstad,AW
中科院分区：
文献类型：
--
作者：
Smejtek,P;Wang,SR;Barstad,AW
We have studied adsorption of pentachlorophenol (PCP) to phosphatidylcholine (PC) membranes by measuring the electrophoretic mobility of multilayered lipid vesicles in PCP solutions. PC vesicles become negatively charged due to the adsorption of ionized PCP, and we have found that their zeta potential depends upon the ionic strength and pH of the aqueous suspension. We have shown that the experimental results can be adequately accounted for in terms of a two-component Langmuir-Stern-Grahame adsorption model assuming that the ‘PCP adsorption sites’ are occupied either by the netural (HA) or the ionized (A−) species. The characteristics of adsorption isotherms of the PCP - PC membrane are as follows the association constants areKA= 55 000 dm3/mol,KHA= 279 000 dm3/mol; 4.3 PC molecules make up each PCP adsorption site at saturation; the linear partition coefficients areβHA= (15.5 ± 0.7)-10t-5m andBA= (3.0 ± 0.3) · 105m. The properties of PCP adsorption isotherms for PC membranes predict an increased pKavalue of membrane-bound PCP, which has been observed in related studies.
