A novel 5-HT receptor ligand and related cytotoxic compounds from an acid mine waste extremophile
A novel 5-HT receptor ligand and related cytotoxic compounds from an acid mine waste extremophile
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DOI：
10.1021/np030044w
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发表时间：
2003-08-01
影响因子：
5.1
通讯作者：
Blake, D
中科院分区：
文献类型：
--
作者：
Stierle, AA;Stierle, DB;Blake, D
蒙大拿州比尤特的伯克利坑湖是一个富含有毒金属的酸性矿山废物库。 Pithomyces sp.从 Pit Lake 中分离得到三种酪氨酸衍生物 (1-3)，其中一种充当 5-HT(2a) 受体配体。这种类型的活性与偏头痛预防药物和抗高血压药物有关。本文报道了先前从高等植物中分离出的化合物 1-3 和三种倍半萜 (5-7) 的分离和表征。
Berkeley Pit Lake in Butte, Montana, is an acid mine waste reservoir rich in toxic metals. A Pithomyces sp. isolated from the Pit Lake yielded three tyrosine derivatives (1-3), one of which acts as a 5-HT(2a) receptor ligand. This type of activity has been associated with migraine preventative and antihypertensive drugs. The isolation and characterization of compounds 1-3 and three sesquiterpenes (5-7) that have been isolated previously from higher plants are reported here.