Effect of varying quantity and quality of dietary protein intake in experimental renal disease in rats.
Effect of varying quantity and quality of dietary protein intake in experimental renal disease in rats.
复制标题
膳食蛋白质摄入量和质量的变化对大鼠实验性肾病的影响。
作者：
A. Williams;F. Baker;J. Walls
已知当肾脏质量减少时，饮食蛋白质限制有益于保护肾功能。本研究探讨两种不同的膳食蛋白质，酪蛋白和大豆，对正常大鼠和大鼠肾次全切除肾功能的影响。饲料是等热量的，具有相同的钠，钾和磷含量。正常大鼠摄入24%大豆蛋白饲料显示较低的有效肾血浆流量和较低的肾小球滤过率比大鼠摄入24%酪蛋白饲料。实验动物进行了单侧肾切除术和对侧部分肾梗死，并喂养酪蛋白或大豆，在24或12%的水平，3个月。那些摄入大豆饲料的动物表现出存活率提高（p <0.05），蛋白尿减少（p <0.02），肾肥大减少（p <0.005）和肾组织学损伤减少。膳食蛋白质的性质似乎会影响正常的肾功能和实验诱导的肾病的进展。
Dietary protein restriction is known to be beneficial in the preservation of renal function when renal mass is reduced. This study investigates the effects of two different dietary proteins, casein and soya, upon renal function in normal rats and rats subjected to subtotal nephrectomy. The diets were isocaloric, with identical sodium, potassium and phosphorus contents. Normal rats ingesting a 24% soya protein diet demonstrate lower effective renal plasma flow rates and lower glomerular filtration rates than rats ingesting a 24% casein diet. Experimental animals were subjected to a unilateral nephrectomy and contralateral partial renal infarction and were fed either casein or soya, at 24 or 12% levels, for 3 months. Those animals ingesting the soya diets demonstrated improved survival (p less than 0.05), less proteinuria (p less than 0.02), less renal hypertrophy (p less than 0.005) and less renal histological damage. The nature of the dietary protein appears to influence both normal renal function and the progression of experimentally induced renal disease.