Oxidation of tris to one-carbon compounds in a radical-producing model system, in microsomes, in hepatocytes and in rats.
Oxidation of tris to one-carbon compounds in a radical-producing model system, in microsomes, in hepatocytes and in rats.
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在产生自由基的模型系统、微粒体、肝细胞和大鼠中，三羟甲基氨基甲烷氧化为一碳化合物。
DOI：
10.3109/10715769109088932
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
R. Kahl
中科院分区：
文献类型：
--
作者：
M. Schäcker;H. Foth;J. Schlüter;R. Kahl
The buffer substance tris(hydroxymethyl)aminomethane (Tris) is converted to formaldehyde in an hydroxyl radical producing model system and in rat liver microsomes, and to CO2 in rat hepatocytes and in the intact rat. In microsomes, formaldehyde formation from Tris is inhibited by catalase, by the antioxidant propylgallate and by the iron chelator deferoxamine, formaldehyde formation is stimulated by the addition of Fe (II) EDTA. In hepatocytes, the formation of [14C] CO2 from [14C] Tris is inhibited by propylgallate and by the iron chelator o-phenanthroline and is stimulated by the presence of a xanthine oxidase system plus Fe (II) EDTA in the medium. In the intact rat, the administration of [14C] Tris results in the exhalation of [14C] CO2. The results indicate that an oxidant formed via a Fenton-type reaction, possibly the hydroxyl radical, may be involved in the formation of one-carbon compounds from Tris.
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在抗坏血酸 tris 缓冲液和纳什试剂存在下测定微粒体异生素 N-去甲基化的伪影。
DOI：
10.3109/00498258809041685
发表时间：
1988
期刊：
Xenobiotica; the fate of foreign compounds in biological systems
影响因子：
--
作者：
Zychlinski,L;Raska-Emery,P;Montgomery,MR
通讯作者：
Montgomery,MR
马来酸二乙酯和佛尔酮在体内和体外对低 Km 线粒体醛脱氢酶的抑制作用。
DOI：
10.1042/bj2400821
发表时间：
1986
期刊：
The Biochemical journal
影响因子：
--
作者：
Dicker,E;Cederbaum,AI
通讯作者：
Cederbaum,AI
大鼠肝微粒体将甘油氧化为甲醛。
DOI：
10.1016/s0006-291x(88)81139-2
发表时间：
1988
影响因子：
3.1
作者：
Winters,DK;Clejan,LA;Cederbaum,AI
通讯作者：
Cederbaum,AI
ADP-铁作为芬顿反应物：通过自旋捕获、夺氢和芳香羟基化检测到的自由基反应。
影响因子：
3.9
作者：
Gutteridge,JM;Nagy,I;Maidt,L;Floyd,RA
通讯作者：
Floyd,RA