Cytotoxic xanthones from Psorospermum molluscum from the Madagascar rain forest.
Cytotoxic xanthones from Psorospermum molluscum from the Madagascar rain forest.
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来自马达加斯加雨林的软疣植物的细胞毒性氧杂蒽酮。
DOI：
10.1021/np070523l
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发表时间：
2008
影响因子：
5.1
通讯作者：
Kingston,DavidGI
中科院分区：
文献类型：
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作者：
Leet,JohnE;Liu,Xiaohong;Drexler,DieterM;Cantone,JosephL;Huang,Stella;Mamber,StephenW;Fairchild,CraigR;Hussain,Raouf;Newman,DavidJ;Kingston,DavidGI
从马达加斯加热带雨林植物Psorospermumcf.mollusumcf.的提取物中分离得到两个新的细胞毒性口山酮。新的二氢呋喃并口香酮，命名为3′，4′-deoxy-4′-chloropsoroxanthin-(3′，5′-diol)(1)和补骨脂(4)，根据2D-核磁共振、MS和UV光谱数据确定了它们的结构，它们与已知的一类植物抗肿瘤药物补骨脂的结构有关。还描述了一种新的羟基戊烯基杂多酮(5)。Xanthone 1和Xanthone 4对ABAE细胞(牛内皮细胞系)具有选择性体外细胞毒作用。
Two new cytotoxic xanthones were isolated from extracts of the Madagascar rain forest plantPsorospermumcf.molluscumusing bioassay-guided fractionation with theEscherichia coliSOS chromotest. The structures of the new dihydrofuranoxanthones, designated 3′,4′-deoxy-4′-chloropsoroxanthin-(3′,5′-diol) (1) and psoroxanthin (4), were determined on the basis of 2D-NMR, MS, and UV spectroscopic data and are structurally related to the psorospermins, a known class of plant antitumor agents. A new hydroxyprenylated xanthone (5) is also described. Xanthones1and4showed selectivein vitrocytotoxicity against ABAE cells (bovine endothelial cell line).