Ovarian Malignant Mixed Germ Cell Tumor Composed Mainly of a Polyembryoma Pattern With Vasculogenic Mesenchymal Tumor Components.
Ovarian Malignant Mixed Germ Cell Tumor Composed Mainly of a Polyembryoma Pattern With Vasculogenic Mesenchymal Tumor Components.
复制标题
卵巢恶性混合生殖细胞肿瘤主要由多胚瘤模式和血管源性间叶质肿瘤成分组成。
DOI：
10.1097/pgp.0000000000000867
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
T. Kishimoto
中科院分区：
文献类型：
--
作者：
Y. Kouchi;Shugo Komatsu;Sakurako Harada;Yoshiki Shinomiya;J. Ikeda;T. Kishimoto
卵巢生殖细胞肿瘤由许多发育良好的胚胎体组成，被描述为“多胚瘤模式”。“此外，一些生殖细胞肿瘤偶尔伴有肿瘤性血管增生。这些包括血管瘤和最近报道的纵隔血管源性间叶肿瘤。一名9岁的日本女孩接受了右侧卵巢肿瘤手术。组织学上，多胚瘤型、非妊娠绒毛膜癌和以胚胎血管发生的肿瘤性重复为特征的血管发生性病变混杂在一起。多胚瘤型由许多完整和不完整的胚体和类似成人型和胎儿型肠的腺结构组成。血管源性病变由粘液瘤间质内各种发育的肿瘤血管组成，其延伸远超过一个低倍（40×）显微镜视野。我们的结论是，血管性病变在我们的情况下，卵巢对应的纵隔血管间叶肿瘤。手术后，患者接受了辅助化疗，术后28个月存活，无复发或其他恶性肿瘤迹象。
Ovarian germ cell tumors composed of numerous well-formed embryonal bodies have been described as exhibiting a "polyembryoma pattern." In addition, some germ cell tumors are occasionally concomitant with neoplastic vascular proliferation. These include angiosarcomas and the recently reported mediastinal vasculogenic mesenchymal tumors. A 9-yr-old Japanese girl underwent surgery for a right ovarian tumor. Histologically, the polyembryoma pattern, nongestational choriocarcinoma, and vasculogenic lesions characterized by a neoplastic repetition of embryonic vasculogenesis have been intermingled. The polyembryoma pattern consisted of numerous complete and incomplete embryonal bodies and glandular structures resembling adult-type and fetal-type intestines. Vasculogenic lesions were composed of variously developed neoplastic vessels within the myxomatous stroma, which extended well beyond one low-power (40×) microscopic field. We concluded that the vasculogenic lesion in our case was the ovarian counterpart of the mediastinal vasculogenic mesenchymal tumor. After the surgery, the patient was administered adjuvant chemotherapy and was alive with no evidence of recurrence or other malignancy at 28 mo postsurgery.