Increased anxiety-like behavior in neuropsin (kallikrein-related peptidase 8) gene-deficient mice
Increased anxiety-like behavior in neuropsin (kallikrein-related peptidase 8) gene-deficient mice
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DOI：
10.1037/0735-7044.122.3.498
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发表时间：
2008-06-01
影响因子：
1.9
通讯作者：
Shiosaka, Sadao
中科院分区：
文献类型：
--
作者：
Horii, Yoichiro;Miyakawa, Tsuyoshi;Shiosaka, Sadao
神经素（钾化钾素相关肽酶8）集中在海马、杏仁核、嗅球和前额皮质。早期研究表明，蛋白酶缺乏会导致Y迷宫和Morris水迷宫中Schaffer侧通路早期长期增强和海马依赖记忆的显著损伤（Z. Chen et al., 1995; a . Hirata et al., 2001； H. Tamura et al., 2006）。除了神经肽参与海马记忆外，杏仁核和皮层的基因定位提示海马外行为功能，因此作者检查了神经肽缺乏的小鼠，包括感觉运动反射、开放场、明暗转换、旋转杆、高架加迷宫、热板、惊吓反应-脉冲前抑制、Porsolt强迫游泳、Bames迷宫、八臂放射状迷宫以及情境和暗示恐惧条件反射测试。在这里，作者发现神经蛋白缺陷小鼠的焦虑增加，表明这种蛋白酶参与情绪反应。
Neuropsin (kallikrein-related peptidase 8) is concentrated in the hippocampus, amygdala, olfactory bulb, and prefrontal cortex. Earlier studies showed that protease deficiency causes a significant impairment of early-phase long-term potentiation in the Schaffer collateral pathway and hippocampus-dependent memory in the Y maze and Morris water maze (Z. Chen et al., 1995: A. Hirata et al., 2001; H. Tamura et al., 2006). In addition to neuropsin's participation in the hippocampal memory, amygdalar and cortical localization of the gene suggests extrahippocampal behavioral function, and the authors therefore examined neuropsin-deficient mice, including tests of sensory motor reflex, open field, light-dark transition, Rota-Rod, elevated plus-maze, hot plate, startle response-prepulse inhibition, Porsolt forced swim, Bames maze, eight-arm radial maze, and contextual and cued fear conditioning tests. Here, the authors found increased anxiety in neuropsin-deficient mice, suggesting the involvement of this protease in emotional responses.