Organelle-targeted nanocarriers: Specific delivery of liposomal ceramide to mitochondria enhances its cytotoxicity in vitro and in vivo
Organelle-targeted nanocarriers: Specific delivery of liposomal ceramide to mitochondria enhances its cytotoxicity in vitro and in vivo
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DOI：
10.1021/nl801908y
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发表时间：
2008-08-01
期刊：
影响因子：
10.8
通讯作者：
Weissig, Volkmar
中科院分区：
文献类型：
--
作者：
Boddapati, Sarathi V.;D'Souza, Gerard G. M.;Weissig, Volkmar
为了进一步提高已知作用于细胞内靶位点的药物的治疗活性，体内药物递送方法必须主动介导药物分子向亚细胞作用位点的特异性递送。我们在此表明，用亲线粒体三苯基鏻阳离子对纳米载体进行表面修饰，有助于将模型药物有效地亚细胞递送至哺乳动物细胞的线粒体，并提高其体外和体内活性。
To further increase the therapeutic activity of drugs known to act on intracellular target sites, in vivo drug delivery approaches must actively mediate the specific delivery of drug molecules to the subcellular site of action. We show here that surface modification of nanocarriers with mitochondriotropic triphenylphosphonium cations facilitates the efficient subcellular delivery of a model drug to mitochondria of mammalian cells and improves its activity in vitro and in vivo.