Neuropsychological performance in HIV‐1‐infected homosexual men
Neuropsychological performance in HIV‐1‐infected homosexual men
复制标题
HIV-1 感染的同性恋男性的神经心理学表现
作者：
E. Miller;O. Selnes;J. Mcarthur;P. Satz;J. Becker;B. Cohen;K. Sheridan;A. Machado;W. V. Gorp;B. Visscher
我们对参加多中心艾滋病队列研究（MACS）的769名HIV-1血清阴性、727名无症状HIV-1血清阳性（CDC第2组和第3组）和84名有症状HIV-1血清阳性（CDC第4组）的同性恋/双性恋男性进行了一系列标准化的神经心理学测量，以评估其认知功能。测量包括注意力、记忆力和精神运动速度的测试。组均值比较显示HIV-1血清阳性和症状性HIV-1血清阳性受试者在记忆测量和强运动和精神运动计时成分测量上的表现存在显著差异。这些发现支持了这些神经心理学工具在检测可能与HIV-1相关的认知变化方面的敏感性，并且与其他关于症状性HIV-1感染个体的神经心理学异常的报道一致。另一方面，无症状血清阳性的男性在任何神经心理学测量上与血清阴性的受试者没有显著差异。只有5.5%的无症状HIV-1血清阳性男性在个体检测中表现异常。这一比例与血清阴性对照无显著差异。此外，在无症状的血清阳性受试者中，我们发现HIV感染持续时间或免疫系统功能水平没有统计学上的显著差异。因此，本研究的结果支持无症状hiv -1感染的男同性恋者神经心理异常的频率较低的假设，与血清阴性对照者没有统计学差异。
We administered a battery of standardized neuropsychological measures to assess cognitive functions in a group of 769 HIV-1 seronagative, 727 asymptomatic HIV-1 seropositive (CDC Groups 2 and 3), and 84 symptomatic HIV-1 seropositive (CDC Group 4) homosexual/bisexual men enrolled in the Multicenter AIDS Cohort Study (MACS). Measures included tests of attention, memory, and psychomotor speed. Comparison of group means revealed significant differences in performance between HIV-1 seropositive and symptomatic HIV-1 seropositive subjects on measures of memory and on measures with strong motor and psychomotor timed components. These findings support the sensitivity of these neuropsychological instruments for detecting cognitive changes that may be related to HIV-1, and are consistent with other reports of neuropsychological abnormalities in symptomatic HIV-1-infected individuals. Asymptomatic seroropositive men, on the other hand, did not differ significantly from seronegative subjects on any of the neuropsychological measures. Only 5.5% of the asymptomatic HIV-1 seropositive men showed abnormal performance on individual tests. This proportion did not differ significantly from that of seronegative controls. Further, among asymptomatic seropositive subjects, we found no statistically significant differences as a function of duration of HIV infection or level of immune system functioning. Thus, results from this study support the hypothesis that the frequency of neuropsychological abnormalities in asymptomatic HIV-1-infected homosexual men is low, and not statistically different from that of seronegative controls.
艾滋病痴呆症的神经心理学特征：初步报告。
DOI：
10.1097/00002030-198804000-00002
发表时间：
1988
期刊：
AIDS (London, England)
影响因子：
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作者：
Tross,S;Price,RW;Navia,B;Thaler,HT;Gold,J;Hirsch,DA;Sidtis,JJ
通讯作者：
Sidtis,JJ