The correlation between ferritin level and acute phase parameters in rheumatoid arthritis and systemic lupus erythematosus
The correlation between ferritin level and acute phase parameters in rheumatoid arthritis and systemic lupus erythematosus
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DOI：
10.5152/eurjrheumatol.2014.032
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发表时间：
2014-09-01
影响因子：
1.9
通讯作者：
Cakir, Necati
中科院分区：
文献类型：
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作者：
Seyhan, Serkan;Pamuk, Omer Nuri;Cakir, Necati
目的：在这项研究中，我们评估铁蛋白水平和疾病的活动在类风湿关节炎（RA）patients.Material和方法：我们包括44例RA患者，20例系统性红斑狼疮（SLE）患者，25例感染，22例恶性肿瘤患者，20名健康对照组。红细胞沉降率（ESR），C反应蛋白（CRP），全血细胞计数，血清铁参数在所有情况下进行了测定。记录RA患者的关节表现，并计算疾病活动性评分（DAS）。在SLE患者中，测定抗核抗体（ANA）和抗dsDNA滴度以及C3和C4补体水平。结果：RA组、SLE组和对照组血清铁蛋白水平均低于感染组和恶性肿瘤组（P< 0.05）。RA组的铁蛋白水平与SLE组和对照组无显著差异。RA患者血清铁蛋白水平与ESR、CRP、RF、血小板计数、DAS评分呈正相关，与红细胞压积呈负相关（P均< 0.05）。另一方面，在SLE患者中，血清铁蛋白与ANA、抗dsDNA和SLEDAI呈正相关（所有p值均< 0.05）。根据DAS，非活动期RA患者的铁蛋白水平低于活动期RA患者。当转铁蛋白饱和被认为是，缺铁性贫血是一个相当频繁的发现在活动和非活动性RA patients.Conclusion：有趣的是，我们观察到，铁蛋白水平在RA患者是类似的对照组，但是，它是一个很好的参数疾病激活。这是因为储存铁减少和由此导致的缺铁性贫血在RA患者中非常常见。
Objective: In this study, we evaluated the relationship between ferritin levels and disease activation in rheumatoid arthritis (RA) patients.Material and Methods: We included 44 patients with RA, 20 patients with systemic lupus erythematosus (SLE), 25 patients with infection, 22 patients with malignancy, and 20 healthy control subjects. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), whole blood count, and serum iron parameters were determined in all cases. The joint findings in RA patients were recorded, and disease activity score (DAS) was calculated. In SLE patients, antinuclear antibody (ANA) and anti-dsDNA titers and C3 and C4 complement levels were determined. SLE disease activity index (SLEDAI) score was calculated.Results: Serum ferritin levels in the RA, SLE, and control groups were lower than those in the infection and malignancy groups (p< 0.05). The ferritin levels in the RA group did not differ significantly from the SLE and control groups. In RA patients, serum ferritin level had a positive correlation with ESR, CRP, RF, platelet count, and DAS score and had a negative correlation with hematocrit (all p values < 0.05). In SLE patients, on the other hand, serum ferritin had a positive correlation with ANA, anti-dsDNA, and SLEDAI (all p values < 0.05). According to DAS, ferritin level in inactive RA patients was lower than that in active RA patients. When transferrin saturation was considered, iron deficiency anemia was a quite frequent finding in both active and inactive RA patients.Conclusion: Interestingly, we observed that ferritin level in RA patients was similar to the control group; however, it was a good parameter of disease activation. This is because a reduction in storage iron and resultant iron deficiency anemia are very common in RA patients.