ALBUMIN MICROSPHERES FOR INTRAARTICULAR DRUG DELIVERY - INVESTIGATION OF THEIR RETENTION IN NORMAL AND ARTHRITIC KNEE JOINTS OF RABBITS
ALBUMIN MICROSPHERES FOR INTRAARTICULAR DRUG DELIVERY - INVESTIGATION OF THEIR RETENTION IN NORMAL AND ARTHRITIC KNEE JOINTS OF RABBITS
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DOI：
10.1111/j.2042-7158.1987.tb06268.x
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发表时间：
1987-04-01
影响因子：
3.3
通讯作者：
DAVIS, SS
中科院分区：
文献类型：
--
作者：
RATCLIFFE, JH;HUNNEYBALL, IM;DAVIS, SS
The retention of 131I-labelled albumin microspheres and microsphere-entrapped [131I]rose bengal was investigated in normal and experimentally arthritic knee joints of rabbits. Albumin microspheres were cleared slowly from the joint cavity and no significant difference was observed between normal and inflamed joints. Entrapment of rose bangal within albumin microspheres was found to delay the clearance of the drug from the joint when compared with a solution of rose bengal. In addition, the retention time for entrapped rose bengal was dependent on the degree of inflammation present.
