Prepulse inhibition and habituation of the startle response are stable neurobiological measures in a normal male population
Prepulse inhibition and habituation of the startle response are stable neurobiological measures in a normal male population
复制标题
DOI：
10.1016/s0006-3223(98)00294-7
复制
发表时间：
1999-02-01
影响因子：
10.6
通讯作者：
Braff, DL
中科院分区：
文献类型：
--
作者：
Cadenhead, KS;Carasso, BS;Braff, DL
前脉冲抑制（PPI）和惊吓反应的习惯化是感觉运动门控和信息处理的操作措施。惊吓反应的正常抑制和习惯化的变化可能为精神分裂症等疾病提供特征标记，这些疾病改变了调节这些措施的神经回路的神经递质控制。在10名正常男性受试者中评估PPI的稳定性和习惯化。发现前脉冲抑制在更强烈的前脉冲条件下最稳定，并且习惯化在测试会话的早期部分最稳定。这些数据支持PPI和习惯化是相对稳定的神经生物学标记物的假设。生物精神病学1999;45：360-364（C）1999年生物精神病学学会。
Prepulse inhibition (PPI) and habituation of the startle response are operational measures of sensorimotor gating and information processing. Changes in the normal inhibition ann habituation of the startle response may provide trait markers for illnesses such as schizophrenia that have altered neurotransmitter control of the neural circuitry that modulates these measures. The stability of PPI and habituation was assessed in 10 normal male subjects. Prepulse inhibition was found to be most stable in the more intense prepulse conditions, and habituation was most stable in the early portion of the test session. These data support the hypothesis that PPI and habituation are relatively stable neurobiological markers. Biol Psychiatry 1999;45:360-364 (C) 1999 Society of Biological Psychiatry.