Cobalamin status and its biochemical markers methylmalonic acid and homocysteine in different age groups from 4 days to 19 years
Cobalamin status and its biochemical markers methylmalonic acid and homocysteine in different age groups from 4 days to 19 years
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DOI：
10.1373/clinchem.2003.019869
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发表时间：
2003-12-01
影响因子：
9.3
通讯作者：
Ueland, PM
中科院分区：
文献类型：
--
作者：
Monsen, AUB;Refsum, H;Ueland, PM
背景资料：最近的数据表明，钴胺素和叶酸的状态，包括代谢标志物甲基丙二酸（MMA）和总同型半胱氨酸（tHcy），在儿童时期，特别是在第一年发生显著变化。方法：在一项横断面研究中，对700名儿童（年龄4天至19岁）测定血清钴胺素、血清和全血叶酸、血浆MMA和tHcy。在前6个月，血清钴胺素。血浆MMA、tHcy和血清叶酸水平均高于对照组。在其他年龄组中检测到的浓度。在6周龄至6月龄的婴儿中，MMA和tHcy浓度的中位数分别为>0.78和>75 mumol/L。在年龄较大的儿童（>6个月）中，血清钴胺素在3-7岁时达到峰值，然后下降，中位血浆MMA保持较低水平（
Background: Recent data indicate that cobalamin and folate status, including the metabolic markers methylmalonic acid (MMA) and total homocysteine (tHcy), undergo marked changes during childhood, particularly during the first year.Methods: Serum cobalamin, serum and whole-blood folate, and plasma MMA and tHcy were determined in a cross-sectional study of 700 children; ages 4 days to 19 years.Results: During the first 6 months, serum cobalamin was. lower than, and plasma MMA, tHcy, and serum folate were higher than the. concentrations detected in the other age groups. In infants 6 weeks to 6 months of age, median MMA and tHcy concentrations were >0.78 and >75 mumol/L, respectively. In older children (>6 months), serum cobalamin peaked at 3-7 years and then decreased, median plasma MMA remained low (