Sleep Measures Expressing 'Functional Uncertainty' in Elderlies' Sleep
Sleep Measures Expressing 'Functional Uncertainty' in Elderlies' Sleep
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DOI：
10.1159/000358083
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发表时间：
2014-01-01
期刊：
影响因子：
3.5
通讯作者：
Ficca, Gianluca
中科院分区：
文献类型：
--
作者：
Conte, Francesca;Arzilli, Cinzia;Ficca, Gianluca
背景：睡眠中“功能不确定性”的概念最初被提出是为了表明中枢神经系统无法通过协调生理过程来维持稳定的状态。虽然功能不确定现象的存在已经在婴儿中表现出来，并在老年人中被假想，但它在老年人中的实际发生从未被系统地研究过。目的：本研究的目的是通过比较健康的老年受试者和青年受试者的睡眠，确定在老年人的睡眠中，睡眠不稳定和碎片化指标作为功能不确定性的标志。方法：我们比较了20名健康老年人(年龄范围65-85岁)和20名年轻人(年龄范围22-32岁)的多导睡眠记录，特别是反映睡眠中功能不确定性的变量，如连续性(如唤醒、觉醒)、稳定性(如状态转换、明显的“功能不确定性”周期)和循环组织参数。结果：所有感兴趣的变量都出现了显著的差异：老年组表现出比年轻人更高的碎片化和不稳定指数，以及更少和更短的周期，在周期中花费的时间百分比更低。结论：我们的结果支持睡眠质量随年龄增长而逐渐下降的假说，表现为明显的睡眠不稳定、碎片化和组织紊乱。我们建议将功能不确定度作为准确的睡眠质量指标纳入老年和睡眠障碍人群的标准睡眠评估中。(C)2014年S.Karger AG，巴塞尔
Background: The notion of 'functional uncertainty' during sleep was first proposed to indicate an inability of the central nervous system to maintain stable states by coordinating physiological processes. While the presence of functional uncertainty phenomena has been shown in infants and hypothesized in the elderly, its actual occurrence in the aged population has never been systematically investigated. Objective: The aim of the study is to identify, in the sleep of aged individuals, indexes of sleep instability and fragmentation as markers of functional uncertainty, by comparing a sample of healthy elderly subjects to one of young adults. Methods: We compared polysomnograhic recordings of 20 healthy elderly subjects (age range 65-85 years) with those of 20 young individuals (age range 22-32 years), with special regard to the variables expressing functional uncertainty in sleep, such as continuity (e.g. arousals, awakenings), stability (e.g. state transitions, periods of marked 'functional uncertainty') and cyclic organization parameters. Results: Significant differences emerged for all variables of interest: the elderly group showed higher indexes of fragmentation and instability than the young, as well as less and shorter cycles, and a lower percentage of time spent in cycles. Conclusion: Our results support the hypothesis of a progressive sleep quality disruption with aging, expressed by pronounced sleep instability, fragmentation and disorganization. We propose that functional uncertainty measures could usefully be included in standard sleep assessments on both aged and sleep-disordered populations as accurate sleep quality indexes. (C) 2014 S. Karger AG, Basel