Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal study.
Fetal and infant exposure to severe Chinese famine increases the risk of adult dyslipidemia: Results from the China health and retirement longitudinal study.
复制标题
胎儿和婴儿经历中国严重饥荒会增加成人血脂异常的风险：中国健康与退休纵向研究的结果
DOI：
10.1186/s12889-017-4421-6
复制
发表时间：
2017-06-14
影响因子：
4.5
通讯作者：
Zou Z
中科院分区：
文献类型：
--
作者：
Wang Z;Li C;Yang Z;Ma J;Zou Z
探讨中国人早期饥荒暴露与成年期血脂异常的关系。我们从2011-2012年中国健康与退休纵向研究（CHARLS）的基线调查中选择了2752名参与者，以评估中国饥荒暴露与成年期血脂异常风险的关系。血脂异常定义为TC（总胆固醇）：HDL-C（高密度脂蛋白胆固醇）比值≥ 5.0或使用降胆固醇药物。饥荒暴露队列按参与者的出生日期分类。二元逻辑回归模型被用来检查早期生活饥饿暴露与血脂异常风险的关系。未暴露队列、胎儿期、婴儿期和学龄前暴露队列的血脂异常患病率分别为15.7%、23.1%、22.0%和18.6%。在调整年龄后，早期生活中暴露于中国饥荒显着增加了成年后的LDL胆固醇浓度。在调整性别和当前家庭经济状况后，胎儿（OR = 1.58; 95%CI：1.23-2.03; P < 0.001）和婴儿（OR = 1.52; 95%CI：1.15-2.00; P = 0.003）阶段暴露队列的血脂异常风险显著高于非暴露队列。性别分层后，我们发现，胎儿（OR = 1.80; 95%CI：1.26-2.57; P = 0.001），婴儿（OR = 1.75; 95%CI：1.17-2.62; P = 0.006）和学龄前（OR = 1.63; 95%CI：1.10-2.42; P = 0.015）阶段暴露于严重饥荒加重了女性成年人血脂异常的风险。然而，在男性成年人中没有观察到类似的关联。早期生活中暴露于严重的中国饥荒可能与女性成年期血脂异常风险较高有关，但与男性成年期无关。这种性别效应可能与中国父母传统上重男轻女的假设或幸存者的偏见有关。本文的在线版本（doi：10.1186/s12889-017-4421-6）包含补充材料，可供授权用户使用。
To explore the associations between the Chinese famine exposure in early life and the dyslipidemia in adulthood. We selected 2752 participants from the baseline survey of China Health and Retirement Longitudinal Study (CHARLS) 2011–2012 to evaluate the associations of early life the Chinese famine exposure with risk of dyslipidemia in adulthood. Dyslipidemia was defined as TC (Total Cholesterol): HDL-C (High-Density Lipoprotein Cholesterol) ratio ≥ 5.0 or use cholesterol lowering drugs. Famine exposure cohorts were categorized by birthdates of participants. Binary logistics regression model was used to examine the associations of early-life famine exposure with the risk of dyslipidemia. The dyslipidemia prevalence of the non-exposed cohort, fetal stage-, infant stage-, and preschool stage-exposed cohorts in adulthood was 15.7%, 23.1%, 22.0%, and 18.6%, respectively. Early-life exposure to the Chinese famine significantly increased LDL cholesterol concentrations in adulthood after adjusted for age. The risks of dyslipidemia in fetal (OR = 1.58; 95% CI: 1.23–2.03; P < 0.001) and infant (OR = 1.52; 95% CI: 1.15–2.00; P = 0.003) stage-exposed cohorts were significantly higher than the non-exposed cohort after adjusted for gender and current family economic status. Following gender stratification, we found that fetal (OR = 1.80; 95% CI: 1.26–2.57; P = 0.001), infant (OR = 1.75; 95% CI: 1.17–2.62; P = 0.006), and preschool (OR = 1.63; 95% CI: 1.10–2.42; P = 0.015) -stage exposure to severe famine aggravated the risk of dyslipidemia in female adults. However, the similar association was not observed for male adults. Early-life exposure to severe Chinese famine could link with the higher dyslipidemia risk in female adulthood, but not in male adulthood. This gender-specific effect might be associated with the hypothesis that parents in China prefer boys to girls traditionally or survivors’ bias. The online version of this article (doi:10.1186/s12889-017-4421-6) contains supplementary material, which is available to authorized users.