Effect of variations in small intestinal glucose delivery on plasma glucose, insulin, and incretin hormones in healthy subjects and type 2 diabetes
Effect of variations in small intestinal glucose delivery on plasma glucose, insulin, and incretin hormones in healthy subjects and type 2 diabetes
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DOI：
10.1210/jc.2004-0334
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发表时间：
2004-07-01
影响因子：
5.8
通讯作者：
Horowitz, M
中科院分区：
文献类型：
--
作者：
O'Donovan, DG;Doran, S;Horowitz, M
餐后血糖的决定因素是有争议的。我们评估了在健康和2型糖尿病患者中，小肠葡萄糖初始输送速率的变化对血糖、血浆胰岛素和肠促胰岛素反应的影响。8名对照组和8名仅通过饮食管理的2型糖尿病患者进行了配对研究。在这两天，受试者接受十二指肠内葡萄糖输注（t=0-120 min）;有一天，输注速率可变，最初更快（3 kcal/min）在t=0和15 min之间以及更慢（0.71 kcal/min）（t=15-120 min），而在另一天，输注速率从t=0至120 min恒定（1 kcal/min）（即在两天均给予120 kcal葡萄糖）。在t=0-180分钟之间，与恒定输注相比，变量输注的血糖、血浆胰岛素和血浆葡萄糖依赖性胰岛素释放多肽更高。在t=0和30分钟之间，与恒定输注相比，变量输注时血浆胰高血糖素样肽-1的升高幅度更大（P
The determinants of postprandial blood glycemia are controversial. We assessed the effects of variations in the initial rate of small intestinal glucose delivery on blood glucose, plasma insulin, and incretin responses in both health and type 2 diabetes. Eight controls and eight patients with type 2 diabetes managed by diet alone underwent paired studies. On both days subjects received an intraduodenal glucose infusion (t=0-120 min); on one day the infusion rate was variable, being more rapid initially (3 kcal/min) between t=0 and 15 min and slower (0.71 kcal/min) subsequently (t=15-120 min), whereas on the other day, the infusion rate was constant (1 kcal/min) from t=0 to 120 min (i.e. on both days 120 kcal of glucose were administered). Between t=0-180 min blood glucose, plasma insulin and plasma glucose-dependent insulin-releasing polypeptide were greater with the variable, compared with the constant, infusion. Between t=0 and 30 min the magnitude of the rise in plasma glucagon-like peptide-1 was greater with the variable, compared with the constant infusion (P