The synthesis of 5-substituted ring E analogs of methyllycaconitine via the Suzuki-Miyaura cross-coupling reaction.
The synthesis of 5-substituted ring E analogs of methyllycaconitine via the Suzuki-Miyaura cross-coupling reaction.
复制标题
通过 Suzuki-Miyaura 交叉偶联反应合成甲基乌头碱的 5-取代环 E 类似物。
DOI：
10.1016/j.bmc.2008.01.050
复制
发表时间：
2008
影响因子：
3.5
通讯作者：
Bergmeier,StephenC
中科院分区：
文献类型：
--
作者：
Huang,Junfeng;Orac,CrinaM;McKay,Susan;McKay,DennisB;Bergmeier,StephenC
合成了新的3，5-二取代环E甲基乌头碱类似物，并在烟碱型乙酰胆碱受体结合实验中进行了评价。通过5-溴烟酸甲酯的Suzuki-Miyaura交叉偶联反应制备了所需的类似物。吡啶与吸电子取代基的Suzuki-Miyaura交叉偶联反应以前没有被广泛描述过。
Novel 3,5-disubstituted ring E analogs of methyllycaconitine were prepared and evaluated in nicotinic acetylcholine receptor binding assays. The desired analogs were prepared through the Suzuki–Miyaura cross-coupling reaction of methyl 5-bromo-nicotinate. The Suzuki–Miyaura cross-coupling reactions of pyridines with electron withdrawing substituents have not been extensively described previously.