Preparation and characterization of a composite biomaterial including starch micro/nano particles loaded chitosan gel
Preparation and characterization of a composite biomaterial including starch micro/nano particles loaded chitosan gel
复制标题
淀粉微/纳米粒子负载壳聚糖凝胶复合生物材料的制备与表征
DOI：
10.1016/j.carbpol.2017.06.095
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发表时间：
2017-10-15
影响因子：
11.2
通讯作者：
Solouk, Atefeh
中科院分区：
文献类型：
--
作者：
Baniani, Dorsa Dehghan;Bagheri, Reza;Solouk, Atefeh
制备了一种温度敏感性壳聚糖水凝胶，可微创注射到皮肤缺损处。采用油包水（W/O）细乳液法制备了淀粉微/纳米粒子。将淀粉颗粒引入壳聚糖水凝胶中，制备可注射温敏水凝胶复合材料。采用翻管法、压缩实验、溶胀实验、XRD、SEM、OM、DLS、UV-vis光谱等方法进行了研究。结果表明，增加交联剂和表面活性剂的含量和搅拌速度导致粒径减小。通过响应面法（RSM）使用实验设计（DOE）对粒度进行建模。由于方差分析（ANOVA），可以在设计空间内通过二次模型预测颗粒尺寸。凝胶化时间和压缩模量的测量表明，粒子的共混物的网络密度和水凝胶的力学性能显着的影响。溶胀实验表明，淀粉颗粒的加入使壳聚糖水凝胶的溶胀系数显著增加。创新的架构，即凝胶中的微/纳米颗粒，可以被认为是用于某些组织工程的双重递送平台或智能支架。(C)2017爱思唯尔有限公司版权所有
Thermosensitive Chitosan hydrogels which can be injected into defects with minimally invasive approach were prepared. Also starch micro/nano particles were synthesized via water-in-oil (W/O) miniemulsion technique. The starch particles were incorporated into the chitosan hydrogel to prepare injectable thermosensitive hydrogel composites. Tube inverting method, compression tests, swelling studies, XRD, SEM, OM, DLS, UV-vis spectroscopy were used for investigations. Results revealed that increasing crosslinker and surfactant contents and stirring rate leads to particle size reduction. Particle size was modeled using design of experiments (DOE) via the response surface method (RSM). Due to analysis of variance (ANOVA), the particle sizes can be predicted by quadratic model within the design space. Gelation time and compressive modulus measurements showed the particles significant influence on the blend network density and hydrogel mechanical properties. Swelling measurements revealed that incorporation of starch particles in chitosan hydrogel increases its swelling coefficient significantly. The innovative architecture, namely micro/nano particles in gel can be considered as a dual delivery platform or smart scaffold for engineering of certain tissues. (C) 2017 Elsevier Ltd. All rights reserved.