Molecular characterization of carbapenem-resistant Klebsiella pneumoniae in a tertiary university hospital in Turkey
Molecular characterization of carbapenem-resistant Klebsiella pneumoniae in a tertiary university hospital in Turkey
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DOI：
10.1016/j.jhin.2013.03.002
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发表时间：
2013-06-01
影响因子：
6.9
通讯作者：
Gunes, T.
中科院分区：
文献类型：
--
作者：
Alp, E.;Percin, D.;Gunes, T.
本研究的目的是确定在土耳其一所三级大学医院中鉴定的碳青霉烯酶耐药肺炎克雷伯菌（CRKP）的耐药基因和遗传关系。在研究期间，从137名患者中分离出CRKP。对94个菌株进行了抗性基因研究。在这些分离株中，大多数CRKP仅产生苯唑西林酶（OXA）-48（91.5%）;然而，4.3%的分离株仅产生新德里金属β-内酰胺酶1（NDM-1），1%同时产生OXA-48和NDM-1，3.2%产生亚胺培南。这项研究将土耳其添加到越来越多的NDM-1产生细菌的国家名单中，并表明NDM-1可能很容易在世界范围内传播。(c)2013年，卫生保健感染协会。由爱思唯尔有限公司出版。保留所有权利。
The aim of this study was to identify the resistance genes and genetic relationship of carbapenemase-resistant Klebsiella pneumoniae (CRKP) identified in a tertiary university hospital in Turkey. During the study, CRKP was isolated from 137 patients. Resistance genes were studied in 94 isolates. Among these isolates, most of the CRKP produced only oxacillinase (OXA)-48 (91.5%); however, 4.3% of the isolates produced only New Delhi metallo-beta-lactamase 1 (NDM-1), 1% produced both OXA-48 and NDM-1, and 3.2% produced imipenem. This study adds Turkey to the growing list of countries with NDM-1-producing bacteria and shows that NDM-1 may easily spread worldwide. (c) 2013 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.