Phosphatase 1 Nuclear Targeting Subunit, a Novel DNA Repair Partner of PARP1
Phosphatase 1 Nuclear Targeting Subunit, a Novel DNA Repair Partner of PARP1
复制标题
磷酸酶 1 核靶向亚基，PARP1 的新型 DNA 修复伙伴
DOI：
10.1158/0008-5472.can-19-0798
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发表时间：
2019
期刊：
影响因子：
11.2
通讯作者：
Pommier Yves
中科院分区：
文献类型：
--
作者：
Murai Junko;Pommier Yves
由于 PARP1 在 DNA 修复、衰老、染色质重塑和转录方面的多种功能，以及四种 PARP 抑制剂的成功临床开发，关于 PARP1 的文献有大量。在本期《癌症研究》中，Wang 及其同事发现磷酸酶 1 核靶向亚基（PNUTS，也称为 PP1R10）是 PARP1 的伙伴，并证明 PNUTS 和 PARP1 在招募到 DNA 损伤位点方面是相互依赖的。由于 PARP1 是癌症治疗的一个重要靶点，而 PNUTS 具有 PARP 依赖性和 PARP1 独立活性，Wang 及其同事的研究结果增加了对 DNA 修复机制的深入了解，并有可能应用于药物靶向和精准治疗。请参阅 Wang 等人的相关文章，第 17 页。 2526
There is extensive literature on PARP1, owing to the multiple functions of PARP1 for DNA repair, aging, chromatin remodeling and transcription, and to the successful clinical development of four PARP inhibitors. In this issue ofCancer Research, Wang and colleagues identified phosphatase 1 nuclear targeting subunit (PNUTS, also referred to as PP1R10) as a partner of PARP1 and demonstrated that PNUTS and PARP1 are interdependent for their recruitment to DNA damage sites. As PARP1 is a prominent target for cancer therapy and PNUTS has PARP-dependent as well as PARP1-independent activities, the findings of Wang and colleagues add insight into DNA repair mechanisms with potential application to drug targeting and precision therapy.See related article by Wang et al., p. 2526