The prognostic relevance of tumor associated macrophages in advanced stage classical Hodgkin lymphoma
The prognostic relevance of tumor associated macrophages in advanced stage classical Hodgkin lymphoma
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DOI：
10.3109/10428194.2011.580026
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发表时间：
2011-10-01
影响因子：
2.6
通讯作者：
Bumbasirevic, Vladimir Z.
中科院分区：
文献类型：
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作者：
Jakovic, Ljubomir R.;Mihaljevic, Biljana S.;Bumbasirevic, Vladimir Z.
虽然霍奇金淋巴瘤(HL)的治疗方法已经有所改善，但识别可靠的预后生物标志物可以更好地对患者进行分层，以便进行更有效的治疗。我们用免疫组织化学方法分析了52例经阿霉素、博莱霉素、长春新碱、达卡巴津等药物治疗的晚期经典型HL患者诊断时CD68+肿瘤相关巨噬细胞(TAMs)的表达与预后的关系。25%CD68+TAMS患者与2例患者相比，大病、血沉升高(对数等级检验，分别为p=0.003，p=0.049，p=0.007)。在多因素分析中，CD68+TAMs、IPS和Gt；2升高以及肿块是影响总生存率的独立预后因素(COX多因素模型，分别为p=0.006，p=0.007，p=0.013)。肿瘤相关巨噬细胞是一个潜在的预后生物标记物，有助于更好地对慢性粒细胞白血病患者进行风险分层。
Although the treatment of Hodgkin lymphoma (HL) has been improved, distinguishing reliable prognostic biomarkers could better stratify patients for more effective treatment. We analyzed the prognostic relevance of CD68+ tumor-associated macrophages (TAMs) by immunohistochemical analysis at diagnosis and standard clinical parameters in 52 ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine)-treated patients with advanced stage classical HL (cHL). Patients with >25% CD68+ TAMs compared to those with 2, bulky disease, elevated erythrocyte sedimentation rate (log-rank test, p = 0.003, p = 0.049, p = 0.007, respectively). In multivariate analysis, increased CD68+TAMs, IPS >2, and bulky disease were identified as independent prognostic factors for overall survival (Cox multivariate model, p = 0.006, p = 0.007, p = 0.013, respectively). Tumor-associated macrophages represent a potential prognostic biomarker which could contribute to better risk stratification of patients with cHL.