Combined Quantification of Liver Perfusion and Function with Dynamic Gadoxetic Acid-enhanced MR Imaging
Combined Quantification of Liver Perfusion and Function with Dynamic Gadoxetic Acid-enhanced MR Imaging
复制标题
DOI：
10.1148/radiol.12110337
复制
发表时间：
2012-06-01
期刊：
影响因子：
19.7
通讯作者：
Zech, Christoph J.
中科院分区：
文献类型：
--
作者：
Sourbron, Steven;Sommer, Wieland H.;Zech, Christoph J.
目的：评估的可行性，通过使用动态对比剂增强（DCE）的磁共振（MR）成像与肝胆对比剂钆塞酸和双入口两室摄取model.Materials和方法：这项研究是由当地机构审查委员会批准，并从所有患者的书面知情同意书。2008年10月至2009年11月期间，在24例神经内分泌肿瘤肝转移患者（13例男性，11例女性;平均年龄59.8岁）中采集数据。在3.0 T下使用标准剂量的钆塞酸和三维序列进行DCE MR成像，每2.2秒采集48个切片的数据，持续5分钟。对于每名患者，通过去卷积计算血浆流量图，并将模型拟合到六个感兴趣的区域曲线。结果进行了评估，拟合优度分析，并在正常出现的肝组织，通过比较灌注参数与文献报道。在动脉和静脉输入functions. Results的选择观察者间的影响进行了assessed.Results：动脉延迟参数，该模型提供了一个很好的适合所有的数据。正常肝组织中的动脉和静脉血浆流量和细胞外体积值与文献中的值相当。平均细胞内摄取速率为每分钟3.4，标准差为每分钟1.9。该模型在所有肿瘤数据中也提供了良好的拟合，产生高动脉血流分数（87%）和较低的摄取（每分钟1.7）。由于在选择的输入functions.Conclusion：动态钆塞酸增强的MR图像的双入口两室摄取模型的分析提出了一种新的和实用的方法，用于测量动脉和静脉灌注和肝功能在一个单一的收购。(c)RSNA，2012年
Purpose: To evaluate the feasibility of quantifying hepatic perfusion and function by using dynamic contrast material-enhanced (DCE) magnetic resonance (MR) imaging with the hepatobiliary contrast agent gadoxetic acid and a dual-inlet two-compartment uptake model.Materials and Methods: The study was approved by the local institutional review board, and written informed consent was obtained from all patients. Data were acquired between October 2008 and November 2009 in 24 patients with hepatic metastases from neuroendocrine tumors (13 men, 11 women; mean age, 59.8 years). DCE MR imaging was performed at 3.0 T with a standard dose of gadoxetic acid and a three-dimensional sequence, with 48 sections of data acquired every 2.2 seconds for 5 minutes. For each patient, a plasma flow map was calculated by means of deconvolution and the model was fitted to six region-of-interest curves. Results were evaluated with goodness-of-fit analysis and, in normal-appearing liver tissue, by comparing perfusion parameters with those reported in the literature. Interobserver effects in the selection of arterial and venous input functions were assessed.Results: With an arterial delay parameter, the model provided a good fit to all data. Values for arterial and venous plasma flow and extracellular volume in normal-appearing liver tissue were comparable to those in the literature. The mean intracellular uptake rate is 3.4 per minute, with a standard deviation of 1.9 per minute. The model also provided a good fit in all tumor data, producing high arterial flow fraction (87%) and lower uptake (1.7 per minute). Bias due to observer-dependent differences in the selection of the input functions was negligible.Conclusion: The analysis of dynamic gadoxetic acid-enhanced MR images with the dual-inlet two-compartment uptake model presents a new and practical approach for measuring arterial and venous perfusion and hepatic function in a single acquisition. (c) RSNA, 2012