SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism.
SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism.
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DOI：
10.1186/2041-9414-4-6
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发表时间：
2013-12-20
期刊：
影响因子：
--
通讯作者：
Kohn KW
中科院分区：
文献类型：
--
作者：
Luna A;Aladjem MI;Kohn KW
一个复杂的网络调节SIRT 1和PARP 1蛋白的活性，并继续被发现。SIRT 1和PARP 1都有一个共同的辅因子烟酰胺腺嘌呤二核苷酸（NAD+）和几个共同的底物，包括DNA损伤反应和昼夜节律的调节因子。我们回顾这个复杂的网络，使用交互式分子相互作用图（MIM）来探索这两种蛋白质之间的相互作用。在这里，我们讨论了NAD +竞争和转录后/翻译反馈机制如何创建一个对环境线索敏感的调控网络，如遗传毒性应激和代谢状态，并研究这些相互作用在DNA修复和最终细胞命运决定中的作用。
An intricate network regulates the activities of SIRT1 and PARP1 proteins and continues to be uncovered. Both SIRT1 and PARP1 share a common co-factor nicotinamide adenine dinucleotide (NAD+) and several common substrates, including regulators of DNA damage response and circadian rhythms. We review this complex network using an interactive Molecular Interaction Map (MIM) to explore the interplay between these two proteins. Here we discuss how NAD + competition and post-transcriptional/translational feedback mechanisms create a regulatory network sensitive to environmental cues, such as genotoxic stress and metabolic states, and examine the role of those interactions in DNA repair and ultimately, cell fate decisions.