Bone and cartilage changes following experimental varus or valgus tibial angulation.
Bone and cartilage changes following experimental varus or valgus tibial angulation.
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实验性胫骨内翻或外翻角度后骨和软骨发生变化。
DOI：
10.1002/jor.1100080414
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Radin,EL
中科院分区：
文献类型：
--
作者：
Wu,DD;Burr,DB;Boyd,RD;Radin,EL
这项工作的目的是确定是否软骨下骨的变化是一个不可分割的一部分，发展的膝关节骨关节病后，实验创造的胫骨成角。在雌性新西兰白色兔中进行三十度内翻或外翻胫骨近端截骨术。骨和软骨的变化进行了评估大体，放射学和组织学。截骨术后34周，严重的软骨变化，包括骨赘、纤维性颤动、细胞柱紊乱和克隆，在过载的髁上明显，伴有软骨下骨密度增加。软骨退化的模式是从其他实验中发现的不同，机械诱导关节。我们的结论是，骨关节病是一个最终的共同途径，机械诱导关节衰竭，并进行性软骨变化与增加软骨下骨密度。
The purpose of this work was to determine whether subchondral bone changes are an integral part of the development of osteoarthrosis of the knee following experimentally created tibial angulation. Thirty degree varus or valgus proximal tibial osteotomies were created in female New Zealand white rabbits. Bone and cartilage changes were assessed grossly, radiologically, and histologically. Thirty‐four weeks following osteotomy, severe cartilage changes, including osteophytes, fibrillation, derangement of cell columns, and cloning, were evident on the overloaded condyle, accompanied by increased subchondral bone density. The pattern of cartilage deterioration was different from that found in other experimental, mechanically induced arthroses. We conclude that osteoarthrosis is a final common pathway for mechanically induced joint failure, and that progressive cartilage change is associated with increased subchondral bone density.