The activation of 5-HT3 receptors evokes GABA release in the spinal cord
The activation of 5-HT3 receptors evokes GABA release in the spinal cord
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DOI：
10.1016/s0006-8993(03)02952-4
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发表时间：
2003-07-18
期刊：
影响因子：
2.9
通讯作者：
Namiki, A
中科院分区：
文献类型：
--
作者：
Kawamata, T;Omote, K;Namiki, A
我们进行了实验，使用微透析方法，以确定是否激活5-HT 3受体增加GABA在脊髓背角的浓度。鞘内灌注的选择性5-HT 3受体激动剂，1-苯基双胍（0.3，1.0和3.0 mM）剂量依赖性，增加GABA的浓度，而谷氨酸和甘氨酸的浓度没有改变。天冬氨酸的浓度仅增加3.0 mM的1-苯基双胍。我们的研究结果提供了直接的证据，5-HT 3受体的激活引起GABA的释放在脊髓背角，可能产生镇痛。(C)2003 Elsevier Science B. V.保留所有权利。
We carried out experiments using a microdialysis method to determine whether activation of 5-HT3 receptors increases the concentration of GABA in the dorsal horn of the spinal cord. Intrathecal perfusion of a selective 5-HT3 receptor agonist, 1-phenylbiguanide (0.3, 1.0, and 3.0 mM) dose-dependently, increased GABA concentration, while concentrations of glutamate and glycine were not changed. The concentration of aspartate was increased only by 3.0 mM of 1-phenylbiguanide. Our results have provided direct evidence that activation of 5-HT3 receptors evokes GABA release in the spinal dorsal horn, possibly producing analgesia. (C) 2003 Elsevier Science B.V. All rights reserved.