Attracted to membranes: lipid-binding domains in plants
Attracted to membranes: lipid-binding domains in plants
复制标题
DOI：
10.1093/plphys/kiaa100
复制
发表时间：
2021-01-13
期刊：
影响因子：
7.4
通讯作者：
Munnik, Teun
中科院分区：
文献类型：
--
作者：
de Jong, Femke;Munnik, Teun
膜对于细胞和细胞器的功能至关重要。由于膜对大多数极性和带电分子是不可渗透的，因此它们提供电化学能量来运输分子，并为特定的酶和细胞过程创建分隔的微环境。膜还负责细胞器之间以及胞吞和胞吐过程中货物的引导运输。此外，膜通过承载受体和信号转导器以及作为脂质第二信使的底物和产物在细胞信号传导中发挥关键作用。阴离子脂质及其与靶蛋白的特异性相互作用在这些过程中发挥着重要作用，而特定的脂质结合域促进了这些过程。多年来，蛋白质晶体学、脂质结合研究、亚细胞定位分析和计算机建模极大地提高了我们对这些结构域如何实现精确结合、它们在信号传导和膜运输以及植物发育和逆境适应中的功能的了解。
Membranes are essential for cells and organelles to function. As membranes are impermeable to most polar and charged molecules, they provide electrochemical energy to transport molecules across and create compartmentalized microenvironments for specific enzymatic and cellular processes. Membranes are also responsible for guided transport of cargoes between organelles and during endo- and exocytosis. In addition, membranes play key roles in cell signaling by hosting receptors and signal transducers and as substrates and products of lipid second messengers. Anionic lipids and their specific interaction with target proteins play an essential role in these processes, which are facilitated by specific lipid-binding domains. Protein crystallography, lipid-binding studies, subcellular localization analyses, and computer modeling have greatly advanced our knowledge over the years of how these domains achieve precision binding and what their function is in signaling and membrane trafficking, as well as in plant development and stress acclimation.