HCV persistence and immune evasion in the absence of memory T cell help
HCV persistence and immune evasion in the absence of memory T cell help
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DOI：
10.1126/science.1088774
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发表时间：
2003-10-24
期刊：
影响因子：
56.9
通讯作者：
Walker, CM
中科院分区：
文献类型：
--
作者：
Grakoui, A;Shoukry, NH;Walker, CM
人类丙型肝炎病毒（HCV）感染的自发消退通常为持续性病毒血症和相关肝病提供长期免疫力。在这里，我们报告说，记忆性CD4+ T细胞是这种保护所必需的。两个免疫黑猩猩再感染前抗体介导的CD4+ T细胞耗竭导致持续的低水平病毒血症，尽管功能性肝内记忆CD8+ T细胞应答。在缺乏足够的CD4+ T细胞帮助的情况下，记忆性CD8+ T细胞对HCV复制的不完全控制与I类主要组织相容性复合物限制性表位中病毒逃逸突变的出现和未能解决HCV感染有关。
Spontaneous resolution of hepatitis C virus (HCV) infection in humans usually affords long-term immunity to persistent viremia and associated liver diseases. Here, we report that memory CD4+ T cells are essential for this protection. Antibody-mediated depletion of CD4+ T cells before reinfection of two immune chimpanzees resulted in persistent, low-level viremia despite functional intrahepatic memory CD8+ T cell responses. Incomplete control of HCV replication by memory CD8+ T cells in the absence of adequate CD4+ T cell help was associated with emergence of viral escape mutations in class I major histocompatibility complex-restricted epitopes and failure to resolve HCV infection.