FGF23 induces expression of two isoforms of NAB2, which are corepressors of Egr-1
FGF23 induces expression of two isoforms of NAB2, which are corepressors of Egr-1
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DOI：
10.1016/j.bbrc.2006.12.011
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发表时间：
2007-02-02
影响因子：
3.1
通讯作者：
Katagiri, Takenobu
中科院分区：
文献类型：
--
作者：
Fukuda, Toru;Kanomata, Kazuhiro;Katagiri, Takenobu
成纤维细胞生长因子23（FGF23）是磷酸盐稳态和骨骼发生的关键体液因子，尽管其细胞内信号传导的性质仍不清楚。最近，锌指转录因子Egr-1被鉴定为肾脏中FGF 23的立即早期反应基因。我们在这里报告，FGF23不仅诱导Egr-1，而且还诱导NAB 2的两种亚型，这是Egr-1的特异性共抑制物。由FGF23诱导的NAB2的两种亚型均定位于细胞核中，并抑制Egr-1的转录活性。因此，由Egr-1和NAB 2建立的负反馈回路可能参与介导FGF 23的生理作用。(c)2006年爱思唯尔公司All rights reserved.
Fibroblast growth factor 23 (FGF23) is a key humoral factor in phosphate homeostasis and skeletogenesis, though the nature of its intracellular signaling is still unclear. Recently, Egr-1, a zinc-finger transcription factor, was identified as an immediate early response gene of FGF23 in the kidney. We report here, that FGF23 induces not only Egr-1 but also two isoforms of NAB2, which are specific co-repressors of Egr-1. Both isoforms of NAB2 induced by FGF23 were localized in the nucleus and suppressed the transcriptional activity of Egr-1. A negative feedback loop established by Egr-1 and NAB2 may thus be involved in mediating the physiological effects of FGF23. (c) 2006 Elsevier Inc. All rights reserved.