Mammalian polyamine metabolism and function.
Mammalian polyamine metabolism and function.
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DOI:
10.1002/iub.230
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发表时间:
2009-09
期刊:
影响因子:
4.6
通讯作者:
Pegg, Anthony E.
中科院分区:
文献类型:
--
作者:
Pegg, Anthony E.
Polyamines are ubiquitous small basic molecules that play multiple essential roles in mammalian physiology. Their cellular content is highly regulated and there is convincing evidence that altered metabolism is involvement in many disease states. Drugs altering polyamine levels may therefore have a variety of important targets. This review will summarize the current state of understanding of polyamine metabolism and function, the regulation of polyamine content, and heritable pathological conditions that may be derived from altered polyamine metabolism.
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