Mammalian polyamine metabolism and function.

Mammalian polyamine metabolism and function.
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DOI:
10.1002/iub.230
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发表时间:
2009-09
期刊:
影响因子:
4.6
通讯作者:
Pegg, Anthony E.
Pegg, Anthony E.
中科院分区:
生物学3区
文献类型:
--
作者:
Pegg, Anthony E.

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多胺是一种普遍存在的碱性小分子,在哺乳动物生理学中起着多种重要作用。它们的细胞含量受到高度调节,并且有令人信服的证据表明,代谢改变参与许多疾病状态。因此,改变多胺水平的药物可能具有多种重要的靶点。本文综述了多胺代谢和功能的认识现状,多胺含量的调节,以及可能来自多胺代谢改变的遗传性病理条件。
Polyamines are ubiquitous small basic molecules that play multiple essential roles in mammalian physiology. Their cellular content is highly regulated and there is convincing evidence that altered metabolism is involvement in many disease states. Drugs altering polyamine levels may therefore have a variety of important targets. This review will summarize the current state of understanding of polyamine metabolism and function, the regulation of polyamine content, and heritable pathological conditions that may be derived from altered polyamine metabolism.
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