Vitamin B12 Optic Neuropathy in Autism
Vitamin B12 Optic Neuropathy in Autism
复制标题
维生素 B12 自闭症视神经病变
DOI：
10.1542/peds.2009-2975
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发表时间：
2010
期刊：
影响因子：
8
通讯作者：
Grant T. Liu
中科院分区：
文献类型：
--
作者：
S. Pineles;R. Avery;Grant T. Liu
膳食维生素B12缺乏被确定为3例自闭症儿童部分可逆性视神经病变的原因。所有受影响的儿童都表现出逐渐的视力丧失。检查发现视神经萎缩，进一步询问饮食发现，所有3名儿童都有严重的食物选择性和高度定型的饮食，导致他们的饮食中几乎完全缺乏动物产品。所有3名儿童的维生素B12水平都很低。肌肉注射维生素B12和维生素B12水平正常化治疗导致所有3名儿童的视觉功能改善。这些病例说明，食物选择性是自闭症的一种已知并发症，可导致维生素缺乏，从而导致视力丧失和视神经萎缩。医生在评估自闭症和视力丧失儿童时必须高度怀疑，以发现这种罕见的视神经萎缩原因。
Dietary vitamin B12 deficiency was identified as a cause of partially reversible optic neuropathy in 3 autistic children. All of the affected children presented with gradual visual loss. Examination revealed optic atrophy, and further questioning regarding diet revealed that all 3 children had severe food selectivity and highly stereotyped diets that resulted in an almost total lack of animal products in their diets. Vitamin B12 levels were low in all 3 children. Treatment with intramuscular vitamin B12 and normalization of vitamin B12 levels resulted in improvement of visual functioning in all 3 children. These cases illustrate that food selectivity, a known complication of autism, can result in vitamin deficiency that can cause visual loss and optic atrophy. Physicians must have a high index of suspicion when evaluating children with autism and visual loss to detect this rare cause of optic atrophy.
影响因子：
1.7
作者：
Bertoglio, Kiah;Hendren, Robert L.
通讯作者：
Hendren, Robert L.
影响因子：
158.5
作者：
LINDENBAUM, J;HEALTON, EB;ALLEN, RH
通讯作者：
ALLEN, RH